15795-60-5Relevant academic research and scientific papers
Water assisted and choline chloride-dimethylurea deep eutectic salts as catalyst towards the attractive reaction of indole, benzaldehyde, and malononitrile
Ruan, Hongli,Lv, Yue,Yu, Shijun,Lv, Chengwei,An, Yue
, p. 1266 - 1274 (2018)
The condensation of indole, benzaldehyde, and malononitrile was relatively rigorous compared with other Yonemitsu type reaction. We described a strategy using catalytic amount of choline chloride-dimethylurea deep eutectic salts as cheap and safe accelerator. We also found that introducing right amount of water in reaction system was crucial. This method tolerates variations in all three components to get desired 3-substituted indoles in satisfactory yields.
Boron/zinc exchange for the conjugate arylation of unsaturated Meldrum's acid derivatives
Jardim, Micaela,Baldassari, Lucas L.,Contreira, Maria Eduarda,Moro, Angélica V.,Lüdtke, Diogo S.
supporting information, (2020/01/31)
An approach for the conjugate arylation reaction of unsaturated Meldrum's acid derivatives is reported. The reaction takes place through a Boron-Zinc exchange reaction between arylboronic acids and diethylzinc and the subsequent transfer of thus generated reactive aryl groups to the β-position of the double bond of the Meldrum's derivatives. The compounds obtained are valuable synthetic intermediates and can give rise to bioactive molecules such as β,β-disubstituted carboxylic acids and amides.
Asymmetrie addition of alkenylstannanes to alkylidene meldrum's acids
Mahoney, Stuart J.,Dumas, Aaron M.,Fillion, Eric
supporting information; experimental part, p. 5346 - 5349 (2010/02/28)
Herein, we describe enantioselective addition of alkenyltin reagents possessing a reactive and sensitive allylic functionality not readily available to other classes of alkenyl metals. This method is enabled by the use of highly electrophilic alkylidene M
