157977-50-9Relevant academic research and scientific papers
Synthesis of 3-carboxy-20-keto steroid, SB 209963, a 5α-reductase inhibitor, by palladium-catalyzed hydroxycarbonylation
Yu, Marvin S.,Baine, Neil H.
, p. 3123 - 3124 (2007/10/03)
SB 209963 was produced in three steps starting from 17β- carboxyandrost-4-en-3-one. A palladium-catalyzed hydroxycarbonylation introduced the carboxylic acid under mild conditions withOUt epimerization at C17. This reaction represents the first example of hydroxycarbonylation of a vinyl halide under neutral conditions.
