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1579822-78-8

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1579822-78-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1579822-78-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,7,9,8,2 and 2 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1579822-78:
(9*1)+(8*5)+(7*7)+(6*9)+(5*8)+(4*2)+(3*2)+(2*7)+(1*8)=228
228 % 10 = 8
So 1579822-78-8 is a valid CAS Registry Number.

1579822-78-8Downstream Products

1579822-78-8Relevant articles and documents

Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors

Zhi, Zhuoer,Zhang, Wenting,Yao, Jingchun,Shang, Yanguo,Hao, Qingjing,Liu, Zhong,Ren, Yushan,Li, Jie,Zhang, Guimin,Wang, Jinxin

, p. 5783 - 5796 (2020/07/14)

Most of the current monoacylglycerol lipase (MAGL) inhibitors function by an irreversible mechanism of action, causing a series of side effects. Herein, starting from irreversible inhibitors, 25 compounds were synthesized and evaluated in vitro for MAGL inhibition, among which, compound 36 showed the most potent inhibitory activity (IC50 = 15 nM). Crucially, docking studies demonstrated that the m-chlorine-substituted aniline fragment occupied a hydrophobic subpocket enclosed by side chains of Val191, Tyr194, Val270, and Lys273, which creatively identify a new key anchoring point for the development of new MAGL inhibitors. Furthermore, in vivo evaluation innovatively revealed that this reversible inhibitor 36 significantly ameliorated depressive-like behaviors induced by reserpine. To the best of our knowledge, this is the first time that reversible inhibitors of MAGL were developed to support MAGL as a potential therapeutic target for depression.

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