157983-33-0Relevant academic research and scientific papers
Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity
Arencibia, Jose M.,Brindani, Nicoletta,Franco-Ulloa, Sebastian,Nigro, Michela,Kuriappan, Jissy Akkarapattiakal,Ottonello, Giuliana,Bertozzi, Sine Mandrup,Summa, Maria,Girotto, Stefania,Bertorelli, Rosalia,Armirotti, Andrea,De Vivo, Marco
, p. 3508 - 3521 (2020)
We previously reported a first set of hybrid topoisomerase II (topoII) poisons whose chemical core merges key pharmacophoric elements of etoposide and merbarone, which are two well-known topoII blockers. Here, we report on the expansion of this hybrid mol
