157984-22-0Relevant academic research and scientific papers
Di-p-nitrobenzyl azodicarboxylate (DNAD): An alternative azo-reagent for the Mitsunobu reaction
Yang, Jianhai,Dai, Liyan,Wang, Xiaozhong,Chen, Yingqi
, p. 1456 - 1462 (2011)
Di-p-nitrobenzyl azodicarboxylate is prepared in 83.6% yield in two steps as a bright yellow solid, which can be used as an azo-reagent in the Mitsunobu reaction. When a chiral secondary alcohol was used, sufficient configurational inversion of alcohol occurred under Mitsunobu conditions. That the hydrazine produced from DNAD is semisoluble in some solvents such as THF and CH 2Cl2 makes it separated easily from the reaction mixture just via filtration. Then the recovered hydrazine compound can be re-exposed to oxidant to produce DNAD. Because DNAD is more stable than DIAD at ambient temperatures and allows easy separation, it is a good alternative azo-reagent for the Mitsunobu reaction.
A FACILE SYNTHESIS OF MERCAPTOPYRAZOLIDINE USEFUL FOR CONSTRUCTION OF THE PENDANT MOIETY OF 1β-METHYLCARBAPENEM L-627
Kumagai, Toshio,Tamai, Satoshi,Abe, Takao,Nagase, Yunosuke,Inoue, Yoshinori,Nagao, Yoshimitsu
, p. 1521 - 1528 (2007/10/02)
A 4-mercaptopyrazolidine derivative (3), which is a synthetic intermediate of the pendant moiety of 1β-methylcarbapenem L-627 (2), was synthesized by a practical method starting from hydrazine hydrate.
