1579963-19-1Relevant academic research and scientific papers
A novel construction of quino-fused tropone skeleton: First synthesis of 12H-benzo[4,5]cyclohepta[1,2-b]quinolin-12-one derivatives
Gao, Wentao,Xing, Xueda,Li, Yang,Lan, Shuai
, p. 2180 - 2189 (2014/03/21)
In the present investigation, the incorporation of both quinoline moiety and tropone ring in a molecule frame work in fused form leading to a series of structurally novel and biologically intriguing quinoline/tropone hybrids 12H-benzo[4,5]cyclohepta[1,2-b]quinolin-12-one derivatives has been first achieved through a simple, and economical two-step procedure, involving the one-pot synthesis of (E)-2-(arylvinyl)quinoline-3-carboxylic acids followed by intramolecular Friedel-Crafts acylation reaction using polyphosphoric acid (PPA).
