1580002-52-3Relevant academic research and scientific papers
Activity of caffeic acid derivatives against Candida albicans biofilm
De Vita, Daniela,Friggeri, Laura,D'Auria, Felicia Diodata,Pandolfi, Fabiana,Piccoli, Francesco,Panella, Simona,Palamara, Anna Teresa,Simonetti, Giovanna,Scipione, Luigi,Di Santo, Roberto,Costi, Roberta,Tortorella, Silvano
, p. 1502 - 1505 (2014)
The aim of this study was to evaluate the caffeic acid (1) and ester derivatives (2-10) against Candida albicans biofilm and to investigate whether these compounds are able to inhibit the biofilm formation or destroy pre-formed biofilm. Caffeic acid ester 7, cinnamic acid ester 8 and 3,4-dihydroxybenzoic acid ester 10 are more active than fluconazole, used as reference drug, both on biofilm in formation with MIC50 values of 32, 32 and 16 μg/mL, respectively, and in the early stage of biofilm formation (4 h) with MIC 50 values of 64, 32 and 64 μg/mL, respectively. These esters result also more active than fluconazole on mature biofilm (24 h), especially 8 and 10 with MIC50 values of 64 μg/mL.
