158001-24-2

Basic information

• Product Name: oxolan-3-ylhydrazine
• Synonyms: oxolan-3-ylhydrazine;(tetrahydrofuran-3-yl)hydrazinehydrochloride
• CAS NO: 158001-24-2
• Molecular Formula: C4H10N2O
• Molecular Weight: 102
• Mol File: 158001-24-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: oxolan-3-ylhydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: oxolan-3-ylhydrazine(158001-24-2)
• EPA Substance Registry System: oxolan-3-ylhydrazine(158001-24-2)

Safety Data

• Hazardous Substances Data: 158001-24-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Research:
Oxolan-3-ylhydrazine is used as a reagent in chemical research for the synthesis of various organic compounds, contributing to the development of new chemical entities and materials.
Used in Pharmaceutical Research:
In the pharmaceutical industry, oxolan-3-ylhydrazine serves as an intermediate in the synthesis of medicinal compounds, aiding in the creation of novel drugs and therapeutic agents.
Used in Corrosion Inhibition:
Oxolan-3-ylhydrazine has the potential to act as a corrosion inhibitor, which can be applied in industries where metal protection is crucial, such as in the manufacturing of automotive and aerospace components.
Used in Medicinal Chemistry and Drug Development:
Its potential applications in medicinal chemistry and drug development make oxolan-3-ylhydrazine a valuable compound for the discovery and design of new pharmaceuticals, potentially leading to advancements in treatment options for various diseases and conditions.

Upstream product

• 1219018-82-2 (+/-)-t-butyl 2-(tetrahydrofuran-3-yl)hydrazinecarboxylate 
• 1429510-46-2 (±)-benzyl 2-(tetrahydrofuran-3-yl)hydrazinecarboxylate 
• 158020-60-1 tert-butyl 2-(dihydrofuran-3(2H)-ylidene)hydrazine-1-carboxylate 
• 453-20-3 3-Hydroxytetrahydrofuran 

Downstream Products

• 57595-23-0 methyl 4-oxotetrahydrofuran-3-carboxylate 
• 158001-25-3 1-(3-tetrahydrofuranyl)-3-methyl-5-amino-1H-pyrazole-4-carbonitrile 
• 1429510-28-0 (±)-ethyl 5-(4-bromo-2-chlorophenyl)-1-(tetrahydrofuran-3-yl)-1H-pyrazole-4-carboxylate 

Relevant articles and documents

COMPOUNDS USEFUL AS KINASE INHIBITORS

This invention relates to novel compounds. The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are useful as inhibitors of Bruton's tyrosine kinase (BTK).The invention also contemplates the use of the compounds for treating conditions treatable by the inhibition of Bruton's tyrosine kinase, for example cancer, lymphoma, leukemia and immunological diseases.

1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones as PDE1 Inhibitors

The present invention provides 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

PYRAZOLOQUINOLINE DERIVATIVES

A compound and/or pharmacologically acceptable salt thereof represented by the formula (I) has PDE9 inhibitory action, so that the intracerebral cGMP concentration is anticipated to be elevated. The PDE9 inhibitory action and the increase in cGMP lead to the improvement of learning and memory behaviors, and the compound (I) has applicability as a therapeutic agent for cognitive dysfunctions in Alzheimer's disease. wherein R1 is a hydrogen atom; R2 is an aromatic ring group, etc.; R3 is a hydrogen atom, etc; R4 is a hydrogen atom; R5 is an oxepanyl group, etc.; R6 is a hydrogen atom.

AMIDE COMPOUNDS USEFUL IN THERAPY

A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof, (I) wherein, R1 and R2 each independently represent H, halogen, CF3, C1-3 alkyl or C1-3 alkoxy; R3 represents C1-6 alkyl, C3-6 cycloalkyl, phenyl (optionally substituted by one or more substituents each independently selected from Ra) or Het (optionally substituted by one or more substituents each independently selected from OH, oxo, or C1-4 alkyl); R4 represents H or C1-3 alkyl; R5 represents C1-6 alkyl (optionally substituted by one or more substituents each independently selected from Rb), C3-6 cycloalkyl (optionally substituted by one or more substituents each independently selected from oxo or OH), or Het2 (optionally substituted by one or more substituents each independently selected from Rd); oxygen atom or 1 sulphur atom, or (c) 1 oxygen atom or 1 sulphur atom, (optionally substituted by one or more substituents each independently selected from OH, oxo or C1-4 alkyl); and R6 represents C1-3 alkyl (optionally substituted by one or more substituents each independently selected from Rf), C3-5 cycloalkyl (optionally substituted by one or more halogen), CN or halogen; where Rf represents halogen or phenyl: and compositions, processes for the preparation, and uses thereof, e.g. in the treatment of endometriosis or uterine fibroids.

6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof

Novel 6-heterocyclyl-pyrazolo[3,4-d]pyrimidin-4-ones, useful in treating cardiovascular disease, are prepared by reacting a 5-amino-1H-pyrazole-4-carboxamide with heterocyclylcarboxaldehyde or by reacting a 5-amino-1H-pyrazole-4-carbonitrile with a heterocyclylcarboxamidine, followed by diazotization and hydrolysis of the resulting 4-amino-6-heterocyclyl-pyrazolo[3,4-d]pyrimidine.