158009-09-7

Basic information

• Product Name: Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, ethyl ester, trans-
• CAS NO: 158009-09-7
• Molecular Formula: C15H30O3Si
• Molecular Weight: 286.487
• Mol File: 158009-09-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, ethyl ester, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, ethyl ester, trans-(158009-09-7)
• EPA Substance Registry System: Cyclohexanecarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, ethyl ester, trans-(158009-09-7)

Safety Data

• Hazardous Substances Data: 158009-09-7(Hazardous Substances Data)

Upstream product

• 3618-04-0 trans-4-hydroxy-cyclohexane carboxylic acid ethyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1402837-76-6 (1S,4r)-4-((S)-2-((S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol 
• 1402837-78-8 (1R,4r)-4-((R)-2-((S)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol 
• 1402837-77-7 (1S,4r)-4-((S)-2-((R)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol 
• 1402837-79-9 (1R,4r)-4-((R)-2-((R)-6-fluoro-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol 
• 1608504-44-4 C₅₀H₄₇FO₇ 
• 1608504-33-1 C₅₀H₄₈O₈ 
• 1608504-21-7 C₂₂H₂₄O₈ 
• 1608504-19-3 C₂₂H₂₃FO₇ 
• 1608504-15-9 C₅₆H₆₂O₈Si 
• 955401-29-3 trans-4-((tert-butyldimethylsilyl)oxy)cyclohexane-1-carboxylic acid 
• 862728-40-3 4-(tert-butyl-dimethyl-silyloxy)-1-ethyl-cyclohexanecarboxylic acid ethyl ester 

Relevant articles and documents

Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors

(-)-Epigallocatechin gallate (EGCG) is the major flavonoid of green tea and has been widely explored for a range of biological activities including anti-infective, anti-inflammatory, anti-cancer, and neuroprotection. Existing structure-activity data for EGCG has been largely limited to exploration of simple ethers and hydroxyl deletion. EGCG has poor drug-like properties because of multiple phenolic hydroxyl moieties and a metabolically labile ester. This work reports a substantial expansion of structure-activity understanding by exploring a range of semi-synthetic and synthetic derivatives with ester replacements and variously substituted aromatic and alicyclic groups containing more drug-like substituents. Structure-activity relationships for these molecules were obtained for Hsp90 inhibition. The results indicate that amide and sulfonamide linkers are suitable ester replacements. Hydroxylated aromatic rings and the cis-stereochemistry in EGCG are not essential for Hsp90 inhibition. Selected analogs in this series are more potent than EGCG in a luciferase refolding assay for Hsp90 activity.

Aminobenzoxazoles as therapeutic agents

A compound of Formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.