158018-53-2 Usage
Chemical Properties
orange powder
Uses
Different sources of media describe the Uses of 158018-53-2 differently. You can refer to the following data:
1. Modified Tetracycline analog
2. Epianhydrochlortetracycline is a secondary degradation product formed by dehydration of epichlortetracycline at the C6 position to aromatise the B ring. Epianchlorhydrotetracycline is an important standard for monitoring tetracycline stability.
Check Digit Verification of cas no
The CAS Registry Mumber 158018-53-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,8,0,1 and 8 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 158018-53:
(8*1)+(7*5)+(6*8)+(5*0)+(4*1)+(3*8)+(2*5)+(1*3)=132
132 % 10 = 2
So 158018-53-2 is a valid CAS Registry Number.
InChI:InChI=1/C22H21ClN2O7/c1-7-8-6-9-16(25(2)3)18(28)15(21(24)31)20(30)22(9,32)19(29)13(8)17(27)14-11(26)5-4-10(23)12(7)14/h4-5,9,16,26-27,31-32H,6,24H2,1-3H3/p+1/t9-,16+,22-/m0/s1
158018-53-2Relevant articles and documents
Semisynthetic analogues of anhydrotetracycline as inhibitors of tetracycline destructase enzymes
Markley, Jana L.,Fang, Luting,Gasparrini, Andrew J.,Symister, Chanez T.,Kumar, Hirdesh,Tolia, Niraj H.,Dantas, Gautam,Wencewicz, Timothy A.
, p. 618 - 633 (2019)
The synthesis and biological evaluation of semisynthetic anhydrotetracycline analogues as small molecule inhibitors of tetracycline-inactivating enzymes are reported. Inhibitor potency was found to vary as a function of enzyme (major) and substrate-inhibitor pair (minor), and anhydrotetracycline analogue stability to enzymatic and nonenzymatic degradation in solution contributes to their ability to rescue tetracycline activity in whole cell Escherichia coli expressing tetracycline destructase enzymes. Taken collectively, these results provide the framework for the rational design of next-generation inhibitor libraries en route to a viable and proactive adjuvant approach to combat the enzymatic degradation of tetracycline antibiotics.
