158040-48-3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 158040-47-2 (E)-(2S,3R,7S,9S,10R,11S,13R)-3-Allyl-13-[1,3]dithian-2-yl-9,11-dimethoxy-5,7-dimethyl-tetradec-4-ene-1,2,10-triol 
• 158040-44-9 Toluene-4-sulfonic acid (E)-(2S,6S,8S)-2-((S)-2,2-diisopropyl-[1,3]dioxolan-4-yl)-8-((2R,3S,5R,6S)-3,6-dimethoxy-5-methyl-tetrahydro-pyran-2-yl)-8-methoxy-4,6-dimethyl-oct-3-enyl ester 
• 158040-45-0 (2R,3S,5R,6S)-2-[(E)-(1S,3S,7R)-7-((S)-2,2-Diisopropyl-[1,3]dioxolan-4-yl)-1-methoxy-3,5-dimethyl-dec-5-en-9-ynyl]-3,6-dimethoxy-5-methyl-tetrahydro-pyran 
• 158040-46-1 (2R,3S,5R,6S)-2-[(E)-(1S,3S,7R)-7-((S)-2,2-Diisopropyl-[1,3]dioxolan-4-yl)-1-methoxy-3,5-dimethyl-deca-5,9-dienyl]-3,6-dimethoxy-5-methyl-tetrahydro-pyran 
• 158040-43-8 (E)-(2S,6S,8S)-2-((S)-2,2-Diisopropyl-[1,3]dioxolan-4-yl)-8-((2R,3S,5R,6S)-3,6-dimethoxy-5-methyl-tetrahydro-pyran-2-yl)-8-methoxy-4,6-dimethyl-oct-3-en-1-ol 
• 158040-42-7 (2S,3S)-3-[(E)-(4S,6S)-6-((2R,3S,5R,6S)-3,6-Dimethoxy-5-methyl-tetrahydro-pyran-2-yl)-6-methoxy-2,4-dimethyl-hex-1-enyl]-butane-1,2,4-triol 

Downstream Products

• 129873-35-4 C₆₈H₁₃₈O₁₀Si₄ 
• 158040-49-4 Toluene-4-sulfonic acid (E)-(2S,3R,7S,9S,10R,11S,13R)-3-allyl-2,10-bis-(tert-butyl-dimethyl-silanyloxy)-13-[1,3]dithian-2-yl-9,11-dimethoxy-5,7-dimethyl-tetradec-4-enyl ester 

Relevant academic research and scientific papers

Formal total synthesis of FK506. Concise construction of the C(10)-C(34) segment via an effective coupling tactic

A formal total synthesis of the potent immunosuppressant FK506 (1) has been achieved via a concise construction of the Merck advanced intermediate (-)-2. Key features of the successful strategy include stereocontrolled σ-bond installation of the trisubsti