158043-52-8

Upstream product

• 13512-31-7 N-(benzyloxycarbonyl)-L-tyrosine methyl ester 
• 158043-51-7 O-ethyl-N-benzyloxycarbonyl-L-tyrosine methyl ester 
• 16679-94-0 N-[(phenylmethoxy)carbonyl]-L-tyrosine 

Downstream Products

• 158043-54-0 (S)-N-Benzyloxycarbonyl-N'-(2-aminoethyl)-1-(4-ethoxybenzyl)ethylenediamine 
• 1419101-00-0 3-aza-1-(4-hydroxybenzyl)pentane-1,5-diamine trihydrochloride 
• 206987-55-5 [(S)-2-(4-Ethoxy-phenyl)-1-formyl-ethyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

NEW METHOD FOR PREPARING EOB-DTPA

The present invention relates to a method for efficiently and economically manufacturing EOB-DTPA using a novel intermediate. The method according to the present invention enables an in-situ process, significantly reduces the amount of ethylenediamine use

A S-1 - (4- ethoxy group phenmethyl ) - 3-aza-pentane -1,5- diamidogen three hydrochloride preparation method

The invention relates to a preparation method of S-1-(4-ethyoxylbenzyl)-3-azapentane-1,5-diaminetrihydrochloride. The preparation method comprises the following steps: adopting L-tyrosine alkyl ester as a starting raw material, carrying out alkylation reaction with bromoethane, carrying out reduction on an obtained product by use of sodium borohydride, carrying out esterification on alkyl sulfonyl chloride, reacting an obtained reaction product with ethylenediamine, removing an amino protective group by hydrogen chloride to obtain the S-1-(4-ethyoxylbenzyl)-3-azapentane-1,5-diaminetrihydrochloride. The preparation method has the advantages of simplicity in operation, mild reaction condition, safety, controllability, high reaction yield and good product purity, and is more suitable for industrial production.

Process for the production of C-substituted diethylenetriamines

The invention relates to a process for the production of C-substituted diethylenetriamines of general formula STR1 in which R1, R2, R3 and R4 have different meanings.