1580458-75-8Relevant academic research and scientific papers
End-substituted homoallylic amine derivatives, a preparing method thereof and uses of the derivatives
-
Paragraph 0282-0284, (2018/03/24)
The invention belongs to the field of chemical medicines, and particularly relates to end-substituted homoallylic amine derivatives, a preparing method thereof and uses of the derivatives. In the method, the end-substituted homoallylic amine derivatives are prepared by allowing a 2-aza-allyl anion to participate, in a high regioselectivity manner, an allylation reaction catalyzed by iridium, and by an intramolecular 2-aza-Cope rearrangement reaction. The derivatives can be synthesized efficiently by the method. The method is simple, convenient and feasible. Prepared compounds have extremely high optical purity. The derivatives prepared by the method can be used for preparing Sertraline and Tametraline which are anti-depression medicines and some natural products.
Ligand-controlled asymmetric arylation of aliphatic α-amino anion equivalents
Zhu, Ye,Buchwald, Stephen L.
supporting information, p. 4500 - 4503 (2014/04/17)
A palladium-catalyzed asymmetric arylation of 9-aminofluorene-derived imines using a chiral dialkylbiaryl phosphine as the supporting ligand has been developed. This transformation allows for enantioselective access to a diverse range of α-branched benzylamines.
