1580477-17-3Relevant academic research and scientific papers
Enantioselective formal α-allylation of nitroalkanes through a chiral iminophosphorane-catalyzed Michael reaction-Julia-Kocienski olefination sequence
Uraguchi, Daisuke,Nakamura, Shinji,Sasaki, Hitoshi,Konakade, Yuki,Ooi, Takashi
, p. 3491 - 3493 (2014)
A two-step sequence for the asymmetric formal α-allylation of nitroalkanes is disclosed. This new methodology relies on the development of a highly diastereo- and enantioselective conjugate addition of nitroalkanes to vinylic 2-phenyl-1H-tetrazol-5-ylsulfones using chiral triaminoiminophosphorane as a requisite base catalyst and subsequent Julia-Kocienski olefination under kinetic conditions.
