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Usage

Uses

Used in Environmental Testing and Research:
2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL is used as a standard for environmental testing and research. It helps in understanding the presence and effects of PCBs in the environment, as well as their impact on human health.
Used in Studies on Thyroid Hormone Levels:
In the field of endocrinology, 2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL is used to study the effects of PCBs on serum thyroid hormone levels in pregnant women and their infants. This is important for understanding the potential developmental and health risks associated with PCB exposure.
Used in Research on Deiodinase Activity:
2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL is also used in research on polychlorinated biphenyl exposure and its effects on deiodinase activity in young infants. Deiodinases are enzymes involved in the regulation of thyroid hormone levels, and understanding their interaction with PCBs can provide insights into the potential health risks of exposure to these chemicals.
Used in Metabolite Research:
Hydroxylated polychlorinated biphenyls (OH-PCBs) are formed as major metabolites of PCBs, including 2,2',3,3',4',5,5'-HEPTACHLORO-4-BIPHENYLOL, through cytochrome P450 enzyme-mediated oxidation. Research on these metabolites helps in understanding the toxicological effects and environmental fate of PCBs.

Upstream product

• 634-83-3 2,3,4,5-tetrachloroaniline 
• 50375-10-5 1,2,4-trichloro-3-methoxybenzene 

Relevant academic research and scientific papers

Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum

Hydroxylated polychlorinated biphenyls (PCBs) have been identified in wildlife and human samples. Most of these compounds are highly chlorinated (penta-hepatachloro) and contain a single meta- or para-hydroxyl group. Using the Cadogan coupling procedure, the following hydroxy-PCBs congeners were synthesized: 2,3,3',4',5-pentachloro-4-biphenylol, 2,3',4,4',5-pentachloro-3-biphenylol, 2',3,3',4',5-pentachloro-4-biphenylol, 2,2',3',4,4'-pentachloro-3-biphenylol, 2,2',3,3',4',5-pentachloro-4-biphenylol, 2,2',3',4,4',5-hexachloro-3-biphenylol, 2,2',3,4',5,5'-hexachloro-4-biphenylol, 2,2',3,3',4',5,5'-heptachloro-4-biphenyl 2,2',3',4,4',5,5'-heptachloro-3-biphenylol, 2,2',3,4',5,5',6-heptachloro-4-biphenylol. Many of these compounds have been detected as residues in human serum and current studies are investigating their activities as agonists and antagonists for several endocrine-mediated responses.

Hydroxylated PCB Derivatives. Synthesis and Structure Elucidation by NMR Spectroscopy and X-Ray Diffraction

Structures of eight PCB derivatives: 2',3,4',5',6-pentachloro-2-biphenylol (1). 2,2',4',5,5'-pentachloro-3-biphenylol (2), 2,2',4',5,5'-pentachloro-4-biphenylol (3), 2',4,4',5,5',6-hexachloro-2-biphenylol (4), 2', 3', 4,4', 5,6,6'-heptachloro-2-biphenylol (5), 2,2',3',4,4',5,5'-heptachloro-3-biphenylol (6), 2,2', 3,3',4',5,5'-heptachloro-4-biphenylol (7) and 2',3',4,4',5,5',6,6'-octachloro-2-biphenylol (8) have been elucidated by use of 1H-NMR chemical shift assignment of 1-8, a heteronuclear 13C-1H chemical shift correlation spectroscopy (C,H-COSY) experiment on 1, mass spectra and high resolution mass spectra of 1-8 and X-ray crystallographic analysis of 4 and 8.All compounds were synthesized by a modification of the aromatic arylation method of Cadogan by coupling the corresponding chloroaniline and chloroanisole in the presence of isoamyl nitrite, followed by demethylation with boron tribomide in CH2Cl.Compound 4 crystallizes in the monoclinic space group P21n (No. 14) with cell dimensions: a = 8.988(2), b = 19.490(3) and c = 10.722(2) Angstroem and V = 1813.8(5) Angstroem-3 with Z = 4.Full-matrix least-squares refinement of 208 parameters gave R = 0.048 for 2195 reflections .Compound 8 crystallizes in the triclinic space group PI (No. 2) with cell dimensions: a = 8.440(2), b = 7.726(2) and c = 13.328(3) Angstroem and V = 780(1) Angstroem-3 with Z = 2.Full-matrix least-squares refinement of 190 parameters gave R = 0.057 for 1551 reflections .