158096-36-7Relevant academic research and scientific papers
Synthesis, Antimicrobial Evaluations, and DNA Photo Cleavage Studies of New Bispyranopyrazoles
Yusuf, Mohamad,Kaur, Manvinder,Sohal, Harvinder Singh
, p. 706 - 713 (2017)
The bispyranopyrazoles (4a, 4b, 4c, 4d, 4e, 4f, 4g) were synthesized from the reactions of dibenzaldehydes (2a, 2b, 2c, 2d, 2e, 2f, 2g) with 3-methylpyrazole-5-one 3 and malononitrile by refluxing under alcoholic medium. The dibenzaldehydes were obtained from the O-alkylation of 3-hydroxybenzaldehyde with suitable 1,ω-dibromoalkanes under the alkaline conditions in the presence of dry EtOH/DMF. The structures of bisheterocyclics were determined from rigorous analysis of their spectral parameters (IR,1H-NMR,13C-NMR, and ESI-MS). The newly prepared compounds were screened for their antimicrobial activity against seven bacterial and five fungal strains. The DNA photo cleavage potential of these compounds was also evaluated by using agarose gel electrophoresis, and bispyranopyrazoles 4b, 4d and 4e exhibited significant level of DNA photocleavage activity.
Biological evaluation of bisbenzaldehydes against four Mycobacterium species
Cappoen, Davie,Forge, Delphine,Vercammen, Frank,Mathys, Vanessa,Kiass, Mehdi,Roupie, Virginie,Anthonissen, Roel,Verschaeve, Luc,Vanden Eynde, Jean Jacques,Huygen, Kris
, p. 731 - 738 (2013/07/25)
A series of bisbenzaldehydes and structurally related analogs, conveniently synthesized via microwave-assisted reactions, were evaluated in vitro against drug susceptible and multi-drug resistant Mycobacterium tuberculosis, against virulent Mycobacterium bovis, against Mycobacterium ulcerans and against two Mycobacterium avium subspecies. Among the 33 substances that were tested, compound 12, i.e. 4,4′-[1,12-dodecanediyl(oxy)]bisbenzaldehyde, emerged as the most promising hit. Its activity was further confirmed in an intracellular growth inhibition assay of M. tb in murine J774 A.1 macrophages. None of the compounds showed significant cytotoxicity on human C3A hepatocytes in a neutral red dye uptake assay and no genotoxicity or mutagenicity was observed as demonstrated by a VITOTOX test and confirmed with a comet assay.
New 1,3,4-bisthiadiazolines: Synthesis, characterization and antimicrobial evaluations
Yusuf, Mohamad,Kaur, Manvinder,Jain, Payal,Solanki, Indu
, p. 470 - 478,9 (2012/12/11)
The bisthiadiazolines 4a-4g have been synthesized in good yields from the cyclization reactions of bisthiosemicarbazones 3a-3g with acetic anhydride. The condensation reaction of dibenzaldehydes 2a-2g with thiosemicarbazide in alcoholic medium provided 3a
A new route to hyperbranched macromolecules: Syntheses of photosensitive poly(aroylarylene)s via 1,3,5-regioselective polycyclotrimerization of bis(aroylacetylene)s
Dong, Hongchen,Zheng, Ronghua,Lam, Jacky W. Y.,Haeussler, Matthias,Qin, Anjun,Tang, Ben Zhong
, p. 6382 - 6391 (2008/02/02)
A new synthetic route to hyperbranched polymers is developed. Polycyclotrimerizations of functional diynes 1-3 initiated by a simple base of piperidine lead to the formation of hyperbranched poly(aroylarylene)s P1-P3 with perfect 1,3,5-regioregularity and
Synthesis and photocyclization of macrocyclic stilbene derivatives
Dyker, Gerald,K?rning, Jutta,Stirner, Wolfgang
, p. 149 - 154 (2007/10/03)
The stereoselectivity of the formation of macrocyclic stilbenes as well as the regioselectivity of their photocyclization are strongly influenced by the length of the connecting alkanediyl chain. The stereoisomers of the macrocyclic stilbenes and the corr
