1581260-92-5Relevant articles and documents
A mild method for the synthesis of carbamate-protected guanidines using the burgess reagent
Maki, Toshikatsu,Tsuritani, Takayuki,Yasukata, Tatsuro
supporting information, p. 1868 - 1871 (2014/05/06)
A simple method for the synthesis of carbamate-protected guanidines from primary amines is described. A variety of thioureas derived from primary amines and isothiocyanates react with the Burgess reagent to give the corresponding guanidines via either a stepwise or one-pot procedure. By tuning the carbamoyl units of isothiocyanates and the Burgess reagent, differentially N,N′-diprotected guanidines can be obtained. Selective deprotection of the products affords N-monoprotected guanidines.