158136-68-6

Basic information

• Product Name: (1E,3aS,3bR,5aR,9aR,9bS,11aS)-1-hydrazinylidene-9a,11a-dimethyl-3,3a,3b,4,5,5a,6,8,9,9b,10,11-dodecahydro-2H-indeno[5,4-f]quinolin-7-one
• CAS NO: 158136-68-6
• Molecular Formula: C₁₈H₂₉N₃O
• Molecular Weight: 303.44
• Mol File: 158136-68-6.mol
• Article Data: 3

Chemical Properties

• Density: 1.37g/cm³
• Refractive Index: 1.695
• CAS DataBase Reference: (1E,3aS,3bR,5aR,9aR,9bS,11aS)-1-hydrazinylidene-9a,11a-dimethyl-3,3a,3b,4,5,5a,6,8,9,9b,10,11-dodecahydro-2H-indeno[5,4-f]quinolin-7-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1E,3aS,3bR,5aR,9aR,9bS,11aS)-1-hydrazinylidene-9a,11a-dimethyl-3,3a,3b,4,5,5a,6,8,9,9b,10,11-dodecahydro-2H-indeno[5,4-f]quinolin-7-one(158136-68-6)
• EPA Substance Registry System: (1E,3aS,3bR,5aR,9aR,9bS,11aS)-1-hydrazinylidene-9a,11a-dimethyl-3,3a,3b,4,5,5a,6,8,9,9b,10,11-dodecahydro-2H-indeno[5,4-f]quinolin-7-one(158136-68-6)

Safety Data

• Hazardous Substances Data: 158136-68-6(Hazardous Substances Data)

Upstream product

• 76318-69-9 4-aza-5α-androstane-3,17-dione 

Downstream Products

• 158136-71-1 17-iodo-4-aza-5α-androsta-16-en-3-one 

Relevant articles and documents

NOVEL PROCESS FOR PREPARING 17 BETA-SUBSTITUTED 4-AZAANDROSTANE DERIVATIVES

The invention relates to a novel process for preparing 17 beta -substituted 4-azaandrostane derivatives of general formula (I) wherein R represents hydrogen or a C1-3alkyl group; R represents a carboxamido group mono- or disubstituted by C1-8alkyl group(s); or a free carboxyl group; or a carboxyl group esterified with a C1-5 alcohol; and the - &cir& _- &cir& _- &cir& _- &cir& _ bond line represents a single or double bond; as well as their salts. The process comprises reacting a 17-halogeno-4-azaandrostene derivative of general formula (II) wherein R and the - &cir& _- &cir& _- &cir& _- &cir& _ bond line are as defined above, and X is chlorine, bromine or iodine, with a primary or secondary alkylamine or a C1-5 alcohol, in dimethylformamide or dimethylsulfoxide medium in the presence of a palladium(II) salt and phosphines or a palladium(II) complex and a tertiary amine base in carbon monoxide atmosphere at a temperature between 35 DEG C and 80 DEG C, then, if desired, transforming an obtained compound of general formula (I) to another compound of general formula (I) by hydrogenation, hydrolysis or salt forming reaction.

17-halogeno-4-azaandrostene derivatives and process for the preparation thereof

The invention relates to novel 4-azaandrostene intermediates of formula (I), STR1 wherein R is hydrogen or a C1-3 alkyl group; X is chlorine, bromine or iodine; and the ---- bond line is a single or double bond.