1581682-01-0Relevant academic research and scientific papers
PROPELLANE DERIVATES AND SYNTHESIS
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Paragraph 0101, (2015/09/28)
Disclosed herein are compounds of the general Formula (I), and methods of synthesizing substituted bicyclo[1.1.1 jpentanes. The synthetic methods described herein use a [1.1.1]propellane, a Group VIII transition metal compound, a hydride source and a reagent that can contribute a substituent to form a substituted bicycIo[1.1.1 ]pentane, such as a compound of the general Formula (I).
A new route to bicyclo[1.1.1]pentan-1-amine from 1-azido-3-iodobicyclo[1.1. 1]pentane
Goh, Yi Ling,Tam, Eric K.W.,Bernardo, Paul H.,Cheong, Choon Boon,Johannes, Charles W.,William, Anthony D.,Adsool, Vikrant A.
, p. 1884 - 1887 (2014/05/06)
From a medicinal chemistry perspective, bicyclo[1.1.1]pentan-1-amine (1) has served as a unique and important moiety. Synthetically, however, this compound has received little attention, and only one scalable route to this amine has been demonstrated. Reduction of an easily available and potentially versatile intermediate, 1-azido-3-iodobicyclo[1.1.1]pentane (2), can offer both a flexible and scalable alternative to this target. Herein, we describe our scrutiny of this reportedly elusive transformation and report our ensuing success with this endeavor.
