1581731-08-9Relevant academic research and scientific papers
Synthesis of thiazolines by copper catalyzed aminobromination of thiohydroximic acids
Lemercier, Berenice C.,Pierce, Joshua G.
supporting information, p. 2074 - 2076 (2014/05/06)
A copper catalyzed aminobromination of alkene tethered thiohydroximic acids is described, providing a rapid approach to unnatural thiazoline scaffolds not readily available via existing methods. Moderate to high yields of bromothiazolines are obtained with alkyl- and aryl-substituted thiohydroximic acid building blocks containing mono-, di-, and trisubstituted alkenes. The reaction provides high levels of 5-exo selectivity, and terminally monosubstituted alkenes result in predominant syn-diastereoselectivity.
