1581757-89-2Relevant academic research and scientific papers
Stereoselective synthesis of thiochromenes via intramolecular tandem thio-michael addition of in situ generated α,β-unsaturated aldehydes
Kinfe, Henok Hadgu,Mebrahtu, Fanuel Mesfin,Makolo, Felix Loka,Moshapo, Paseka Thendo,Manana, Mandlenkosi Maxwell
, p. 3111 - 3118 (2014/05/06)
An efficient and highly stereoselective strategy for the synthesis of 2,3-substituted thiochromenes having a complex and easily transformable group at the stereogenic center has been developed via a tandem thio-Michael addition reaction of an in situ generated α,β-unsaturated aldehyde sugar derivative. The protocol is superior to reported protocols in that the carbohydrate-derived substituent at the stereogenic center of the thiochromene is versatile and is amenable for further transformation.
