158183-36-9

Upstream product

• 158183-35-8 methyl 2,4-dibenzyloxy-3-methoxy-6-methylbenzoate 
• 34874-90-3 methyl haematommate 
• 72935-23-0 methyl 2,4-dibenzyloxy-3-hydroxy-6-methylbenzoate 
• 72935-22-9 bis(benzyloxy)-2,4-formyl-3-methyl-6-benzoate de methyle 

Downstream Products

• 158183-37-0 methyl 4-(4'-benzyloxy-2'-hydroxy-6'-methylbenzyloxy)-2-hydroxy-3-methoxy-6-methylbenzoate 
• 158183-41-6 6-benzyl 2-methyl 3,9-dihydroxy-4-methoxy-1,7-dimethydibenzofuran-2,6-dicarboxylate 
• 158183-40-5 benzyl 4-hydroxy-2-(3'-hydroxy-2'-methoxy-4'-methoxycarbonyl-5'-methylphenoxy)-6-methylbenzoate 
• 158183-38-1 4-benzyloxy-2-(3'-hydroxy-2'-methoxy-4'-methoxycarbonyl-5'-methylphenoxy)-6-methylbenzoic acid 
• 158183-39-2 4-hydroxy-2-(3'-hydroxy-2'-methoxy-4'-methoxycarbonyl-5'-methylphenoxy)-6-methylbenzoic acid 

Relevant academic research and scientific papers

New Aromatic Compounds from the Fruiting Body of Sparassis crispa (Wulf.) and Their Inhibitory Activities on Proprotein Convertase Subtilisin/Kexin Type 9 mRNA Expression

Successive chromatography of EtOAc-soluble extracts of the fruiting body of Sparassis crispa (Wulf.) resulted in isolation of four new aromatic compounds, sparoside A (1) and sparalides A-C (3-5), two new naturally occurring compounds, 2 and 6, and eight known compounds, 7-14. The chemical structures were determined by interpretation of nuclear magnetic resonance and mass spectrometry spectroscopic data. Extract, solvent-soluble fractions of the extract, and all of the pure compounds isolated from the fractions were subjected to the mRNA expression assay for proprotein convertase subtilisin/kexin type 9 (PCSK9). Among them, sparoside A (1), hanabiratakelide A (8), adenosine (11), and 5α,6α-epoxy-(22E,24R)-ergosta-8(14),22-diene-3β,7β-diol (14) exhibited potent inhibitory activities on PCSK9 mRNA expression, with IC50 values of 20.07, 7.18, 18.46, and 8.23 μM, respectively (berberine, positive control, IC50 = 8.04 μM), suggesting that compounds 1, 8, 11, and 14 are suitable for use in supplements to the statins for hyperlipidemia treatments.

The Structure and Synthesis of 4-Oxypannaric Acid 2-Methyl Ester, a Dibenzofuran from the Lichen Leproloma diffusum

The structure of the major dibenzofuran present in the lichen Leproloma diffusum has been shown to be that of 4-oxypannaric acid 2-methyl ester (2-methyl hydrogen 3,4,9-trihydroxy-1,7-dimethyldibenzofuran-2,6-dicarboxylate) (2).The structure of (2) was co