158196-99-7Relevant academic research and scientific papers
Synthesis, characterization, and antimicrobial evaluation of some new hydrazinecarbothioamide, 1,2,4-triazole and 1,3,4-thiadiazole derivatives
Ulusoy Guezeldemirci, Nuray,Satana, Dilek,Kuecuekbasmaci, Oemer
, p. 968 - 973 (2013)
In this work, we reported the synthesis and evaluation of antibacterial and antifungal activities of three new compound series obtained from 6-(phenyl/4-chlorophenyl)imidazo[2,1-b]thiazole-3-acetic acid hydrazide: 2-{[6-(phenyl/4-chlorophenyl)imidazo[2,1-
Synthesis and biological evaluation of new imidazo[2,1-b]thiazole derivatives as anticancer agents
Karaman, Berin,Ulusoy Güzeldemirci, Nuray
, p. 2471 - 2484 (2016)
A series of arylidenehydrazide compounds (3a–3j) were synthesized from [6-(4-chlorophenyl)imidazo[2,1-b]thiazol-3-yl]acetic acid hydrazide. The newly synthesized compounds 3b and 3h were subjected to the National Cancer Institute’s in vitro disease-oriented antitumor screening to be evaluated for antitumor activity. Compound 3b, the most potent compound examined, displayed broad spectrum antiproliferative activity against all of the tested cell lines with log10GI50 values between ?4.41 and ?6.44. The greatest growth inhibitions were observed against an ovarian cancer cell line(OVCAR-3), a colon cancer cell line (HCT-15), two renal cancer cell lines (CAKI-1 and UO-31) and two leukemia cell lines (CCRF-CEM and SR) with log10GI10 values ?6.44, ?6.33, ?6.11, ?6.30, ?6.13 and ?6.22, respectively.[InlineMediaObject not available: see fulltext.]
Novel imidazo[2,1-b]thiazole-based anticancer agents as potential focal adhesion kinase inhibitors: Synthesis, in silico and in vitro evaluation
Ba?o?lu, Faika,Ulusoy-Güzeldemirci, Nuray,Akal?n-?ift?i, Gül?en,?etinkaya, Serap,Ece, Abdulilah
, p. 270 - 282 (2021/06/16)
The purpose of this study was to synthesize imidazo[2,1-b]thiazole derivatives, characterize them with spectroscopical techniques and investigate for cytotoxic and apoptotic effects on glioma C6 cancer cell line. The in vitro anticancer activities were al
Imidazothiazole derivatives. XI. Modulation of the CD2-receptor of human T trypsinized lymphocytes by several imidazothiazoles
Harraga, S.,Nicod, L.,Drouhin, J. P.,Xicluna, A.,Panouse, J. J.,et al.
, p. 309 - 316 (2007/10/02)
About 40 substituted imidazothiazoles were obtained in order to study their in vitro immunological effect on the modulation of the expression of human T trypsinized lymphocytes by the CD2 receptor.A synthetic program was developed to introduce either an oxygenated function, such as ester (11, 14), acid (12) and arylketonic groups (9, 13, 15), or two groups, such as an aryl and an ester (1, 6, 8), an acid (3, 7) or a hydrazide (2).These compounds were examined by an E-rosette-forming-cell test, and display a positive drug efficacity index, suggesting a regeneration effect on the expression of CD2 receptors.The following structural parameters are favourable: an aryl moiety on the C-6 with a methoxy or nitro group: and an ethyl ester on the C-3, a double bond to the 2,3-position (the 5,6-position is ineffective).Acid and hydrazide functions or the loss of phenyl group on the C-6 decrease this activity.If the aryl group is on the C-3 or C-2 side chain, the activity is weaker and more so for the latter.However, the most interesting derivatives are less immunostimulating than levamisole hydrochloride. immunomodulator / imidazothiazole / human T lymphocyte / CD2 receptor
