1582270-99-2Relevant academic research and scientific papers
Synthesis, characterization and antitumor activity of novel triazole/isoxazole tagged pyridine hybrids
Raju,Chandra Shekhar,Sathaiah,Ravi Kumar,Narsaiah,Shanthan Rao,Srujana,Kotamraju, Srigiridhar
, p. 293 - 302 (2014/05/20)
A series of novel 2-((1-substituted-1H-1,2,3-triazol-4-yl/3- substitutedisoxazol-5-yl)methoxy) substituted pyridine, 1-((1-substituted-1H-1, 2,3-triazol-4-yl/3-substitutedisoxazol-5-yl)methyl)substituted pyridin-2(1H)-one was prepared from 2-oxo-6-phenyl/methyl-4-(trifluoromethyl)-1,2- dihydropyridine-3-carbonitrile 3 via propargylation followed by 1,3-dipolar cycloaddition of the propargyl derivatives 4 and 5. These triazole/isoxazole tagged pyridine derivatives were evaluated for antitumor activity against breast cancer cell lines such as MDA-MB-231, MCF-7 etc. The results indicated that compounds 6e, 6f, 8e and 8f were found to be active on MDA-MB-231, while 6h and 8h were active on MCF-7.
