1582297-29-7Relevant academic research and scientific papers
N -aminoimidazolidin-2-one peptidomimetics
Doan, Ngoc-Duc,Hopewell, Robert,Lubell, William D.
, p. 2232 - 2235 (2014)
The synthesis of N-aminoimidazolidin-2-one (Aid) peptidomimetics has been achieved by alkylation of the urea nitrogen of a semicarbazone residue using ethylene bromide. The Aid scaffold combines electronic and structural constraints to rigidify the peptide backbone in the equivalent of an aza variant of a Freidinger-Veber lactam. The syntheses and isolation of 25 Aid peptides, including eight GHRP-6 analogues, are reported to demonstrate the utility of this method for controlling conformation.
