1582309-56-5Relevant articles and documents
The synthesis and bioactivity of dimethyl (2,3-dihydrobenzo[b][1,4]dioxin- 6-yl)(aryl amino)methylphosphonates
Sundar, Ch. Syama,Reddy, N. Bakthavatchala,Prasad, S. Siva,Rao, K. Uma Maheswara,Prakash, S. H. Jaya,Reddy, C. Suresh
supporting information, p. 551 - 557 (2014/04/03)
A new series of α-aminophosphonates have been synthesized by a one-pot three-component reaction of 2,3-dihydrobenzo[b][1,4]dioxine-6- carbaldehyde, various amines, and dimethyl phosphite by using nano-TiO 2 as a catalyst under solvent-free conditions at 50°C. The major advantages of the present method are high yields, short reaction times, recyclable catalyst, and solvent-free reaction conditions. Among these new structurally diversified set of α-aminophosphonates, dimethyl (2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(3-nitrophenylamino) methylphosphonate and dimethyl (2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(4-fluoro-3-nitro-phenyl-amino) methylphosphonate have shown higher antioxidant activity in diphenyl picryl hydrazyl (DPPH) scavenging, reducing power assay, and lipid peroxidation methods.