1582316-75-3

Upstream product

• 924107-85-7 2-bromo-N-(2-methoxyphenyl)benzenesulfonamide 
• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 1582316-68-4 2-bromo-N-(but-3-en-1-yl)-N-(2-methoxyphenyl)benzenesulfonamide 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 1582316-82-2 2-(2-methoxyphenyl)-3'-phenyl-3,4-dihydro-2H,4'H-spiro[benzo[f][1,2]thiazepine-5,5'-isoxazole] 1,1-dioxide 

Relevant academic research and scientific papers

Benzonitrile oxide cycloadditions with exocyclic methylene benzothiazepine dioxides

N-substituted 5-methylene-2,3,4,5-tetrahydrobenzo[f][1,2]thiazepine 1,1-dioxides underwent 1,3-dipolar cycloaddition with benzonitrile oxide, generated in situ, to give isoxazoline spiro adducts. The cycloadditions were completely regioselective to give the hitherto unreported 3,4-dihydro-2H, 4′ H-spiro[benzo[f][1,2]thiazepine-5, 5′-isoxazole] 1,1-dioxide cycloadduct. Where the N-substituent on the sulfonamide cycloaddition precursor was a 2-substituted arene, the resulting atropisomerism along the N-aryl bond led to facial selectivity in the cycloaddition reaction, with greater than 90% diastereoselectivity. CSIRO 2014.