158299-82-2Relevant academic research and scientific papers
(Cyanomethylene)phosphoranes as Novel Carbonyl 1,1-Dipole Synthons: An Efficient Synthesis of α-Keto Acids, Esters, and Amides
Wasserman, Harry H.,Ho, Wen-Bin
, p. 4364 - 4366 (1994)
Carboxylic acids react with (cyanomethylene)triphenylphosphorane in the presence of EDCI to form cyano keto phosphoranes.The resulting ylides may then be oxidatively cleaved with ozone to form α,β-diketonitriles.These highly electrophilic products may then be converted in situ to α-keto acids, esters, and amides.
