1583253-71-7

Basic information

• Product Name: C₆₀H₈₆O₁₉
• CAS NO: 1583253-71-7
• Molecular Weight: 1111.33
• Mol File: 1583253-71-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₆₀H₈₆O₁₉(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₀H₈₆O₁₉(1583253-71-7)
• EPA Substance Registry System: C₆₀H₈₆O₁₉(1583253-71-7)

Safety Data

• Hazardous Substances Data: 1583253-71-7(Hazardous Substances Data)

Downstream Products

• 103614-76-2 halichondrin B 

Relevant articles and documents

Unified, Efficient, and Scalable Synthesis of Halichondrins: Zirconium/Nickel-Mediated One-Pot Ketone Synthesis as the Final Coupling Reaction

Unified, efficient, and scalable syntheses of the halichondrin natural products are reported. A newly developed Zr/Ni-mediated one-pot ketone synthesis was used to couple the two halves of the final product at a late stage in the synthesis. With the use of a slight excess of the left halves, the desired ketones were isolated in yields of 80–90 %. The halichondrins were obtained from these ketones in two steps, namely desilylation and [5,5]-spiroketal formation. The new synthetic route was effective for the total synthesis of all members in the homohalichondrin subgroup. The scalability of this process was demonstrated with halichondrin B; 150 mg of halichondrin B (68 % overall yield) were obtained from 200 mg of the right-half precursor.