1583264-46-3Relevant academic research and scientific papers
[8+2]formal cycloaddition reactions of tropones with azlactones under bronsted acid catalysis and synthesis of α-(2-tropyl), α-alkyl α-amino acids
Esteban, Francisco,Alfaro, Ricardo,Yuste, Francisco,Parra, Alejandro,Ruano, Jose Luis Garcia,Aleman, Jose
, p. 1395 - 1400 (2014/03/21)
The reaction of tropones with azlactones catalyzed by Bronsted acids affords a variety of dihydro-2H-cyclohepta[b]furan derivatives, corresponding to a formal [8+2] cycloaddition process. They can easily be opened by nucleophiles to afford a new type of α,α-disubstituted α-amino acid (or peptide) containing seven-membered rings at the quaternary position. The reaction of tropones with azlactones catalyzed by Bronsted acids affords a variety of dihydro-2H-cyclohepta[b]furan derivatives, corresponding to a formal [8+2] cycloaddition process. They can be easily opened by nucleophiles to afford a new type of α,α-disubstituted α-amino acid (or peptide) containing seven-membered rings at the quaternary position. Copyright
