15833-22-4

Usage

Uses

Used in Pharmaceutical Industry:
Imidazo[1,2-a]pyridine-3-carboxanilide is used as a potential anti-cancer agent for its ability to inhibit the growth of cancer cells. It is being studied for its potential to target and treat various types of cancer due to its biological activity.
Used in Anti-inflammatory Applications:
Imidazo[1,2-a]pyridine-3-carboxanilide is used as an anti-inflammatory agent, leveraging its properties to potentially treat inflammatory diseases by reducing inflammation and associated symptoms.
Used in Antimicrobial Applications:
Imidazo[1,2-a]pyridine-3-carboxanilide is used as a potential antibacterial and antifungal agent, showing promise in combating microbial infections due to its antimicrobial activity.
These applications highlight the compound's versatility and potential impact on various areas of healthcare, making it an area of interest for ongoing research and development.

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 64951-08-2 imidazo[1,2-a]pyridine-2-carboxylic acid 

Relevant academic research and scientific papers

Palladium-Catalyzed Decarboxylative ortho -Amidation of Indole-3-carboxylic Acids with Isothiocyanates Using Carboxyl as a Deciduous Directing Group

Palladium-catalyzed ortho-amidation of indole-3-carboxylic acids with isothiocyanates by using the deciduous directing group nature of carboxyl functionality to afford indole-2-amides is demonstrated. Both C-H functionalization and decarboxylation took place in one pot, and hence, this carboxyl group served as a unique, deciduous (or traceless) directing group. This reaction offers a broad substrate scope as demonstrated for several other heterocyclic carboxylic acids like chromene-3-carboxylic acid, imidazo[1,2-a]pyridine-2-carboxylic acid, benzofuran-2-carboxylic acid, pyrrole-2-carboxylic acid, and thiophene-2-carboxylic acid. In the reaction using 2-naphthoic acid, of the two possible isomers, only one isomer of the amide was exclusively formed. The indole-2-amide product underwent palladium-catalyzed C-H functionalization to afford the diindole-fused 2-pyridones by combining two molecules of the indole moiety, with the elimination of an amide group from one of them, attached at the C3-position for the C-C/C-N bond formation. The structures of key products are confirmed by X-ray crystallography.