158365-55-0

Basic information

• Product Name: 7-Methoxynaphthalene-1-carboxaldehyde
• Synonyms: 7-Methoxynaphthalene-1-carboxaldehyde;7-Methoxy-1-naphthaldehyde;7-Methoxy-1-naphthalenecarboxaldehyde;1-Naphthalenecarboxaldehyde, 7-Methoxy-
• CAS NO: 158365-55-0
• Molecular Formula: C₁₂H₁₀O₂
• Molecular Weight: 186.2066
• Product Categories: Aromatics;Fluorescent Labels & Indicators;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 158365-55-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7-Methoxynaphthalene-1-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Methoxynaphthalene-1-carboxaldehyde(158365-55-0)
• EPA Substance Registry System: 7-Methoxynaphthalene-1-carboxaldehyde(158365-55-0)

Safety Data

• Hazardous Substances Data: 158365-55-0(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 158365-55-0 differently. You can refer to the following data:
1. One of the two highly fluorogenic aldehydes, 7-Methoxy-1-naphthaldehyde (MONAL-71) and 6-Methoxy-2-naphthaldehyde (MONAL-62), as indicators of the aldehyde dehydrogenase (ALDH) activity in human tissue homogenates and accessible body fluids.
2. One of the two highly fluorogenic aldehydes, 7-Methoxy-1-naphthaldehyde (MONAL-71) and 6-Methoxy-2-naphthaldehyde (MONAL-62), as indicators of the aldehyde dehydrogenase (ALDH) activity in human tissue homogenates and accessible body fluids.This compound is suitable for aldehyde dehydrogenase (ALDH) related research.

Upstream product

• 6836-19-7 7-Methoxy-1-tetralone 
• 1095930-99-6 7-methoxy-1-vinylnaphthalene 
• 64-18-6 formic acid 
• 5060-82-2 7-methoxy-2-naphthol 
• 30021-91-1 6-methoxy-4-methyl-1,2-dihydronaphthalene 
• 66240-21-9 1-iodo-7-methoxynaphthalene 
• 68-12-2 N,N-dimethyl-formamide 
• 158365-54-9 1-cyano-7-methoxynaphthalene 
• 606492-95-9 C₁₂H₁₄O₂ 

Downstream Products

• 178366-52-4 1-chloromethyl-7-methoxynaphthalene 
• 138112-76-2 agomelatine 
• 138113-09-4 2-(7-methoxynaphth-1-yl)ethylamine 
• 144876-32-4 7-hydroxy-1-naphthaldehyde 

Relevant articles and documents

Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties

New multi-target indole and naphthalene derivatives containing the oxadiazolone scaffold as a bioisostere of the melatonin acetamido group have been developed. The novel compounds were characterized at melatonin receptors MT1R and MT2/sub

Synthesis of 1-naphthaldehydes via the cascade reactions of 1-phenylpent-4-yn-2-ols promoted by iodine monochloride

A novel and convenient synthesis of 1-naphthaldehydes through iodine monochloride promoted cascade reactions of 1-phenylpent-4-yn-2-ols is presented. Compared with literature procedures, this new method has advantages such as simple operation procedure, mild reaction conditions, good efficiency, and excellent regio-selectivity.

A facile synthesis of melatonergic antidepressant agomelatine

Agomelatine was synthesized from 8-aminonaphthalen-2-ol by diazotization-iodination, formylation, C-C bond formation by nitroaldol and Pd/C hydrogenation of β-nitrovinylnaphthalene followed by N-acetylation. The route reported employs readily and commercially viable starting materials and reagents, and can potentially be utilized for process synthesis of agomelatine.