158400-45-4Relevant academic research and scientific papers
Substituted azolone derivatives
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, (2008/06/13)
The use for the manufacture of a medicament for treating Helicobacter-related diseases of a compound of formula STR1 a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein X and Y each independently are CH or N; R1, R2 and R3 each independently are hydrogen or C1-4 alkyl; R4 and R5 each independently are hydrogen, halo, C1-4 alkyl, C1-4 alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; Z is C=O or CHOH; and Ar is phenyl optionally substituted with up to three substituents selected from hydroxy, C1-4 alkyl, C1-4 alkyloxy, halo, trifluoromethyl, triC1-4 alkylsilyloxy, nitro, amino and cyano or pyridinyl substituted with hydroxy or C1-4 alkyloxy; and --A-- is a radical of formula STR2
