1584133-08-3Relevant academic research and scientific papers
Highly efficient and scalable synthesis of clionamine D
Wang, Sha-Sha,Shi, Yong,Tian, Wei-Sheng
, p. 2177 - 2179 (2014)
Herein we describe an efficient and scalable synthesis of clionamine D (4), a special member with autophagy bioactivity and an unprecedented spirobislactone side chain in the novel aminosteroid clionamines. This synthesis features a quick access to α-methylene-γ-lactone 8 and a Mn(OAc)3-mediated radical [3 + 2] reaction to assemble the unique spirobislactone unit. Clionamine D (4) can also serve as a key synthetic precursor to other clionamine members.
