158429-03-9Relevant articles and documents
Water-soluble PDE4 inhibitors for the treatment of dry eye
Govek, Steven P.,Oshiro, Guy,Anzola, John V.,Beauregard, Clay,Chen, Jasmine,Coyle, Avery R.,Gamache, Daniel A.,Hellberg, Mark R.,Hsien, Jennifer N.,Lerch, Julia M.,Liao, John C.,Malecha, James W.,Staszewski, Lena M.,Thomas, David J.,Yanni, John M.,Noble, Stewart A.,Shiau, Andrew K.
scheme or table, p. 2928 - 2932 (2010/08/06)
PDE4 inhibitors have the potential to alleviate the symptoms and underlying inflammation associated with dry eye. Disclosed herein is the development of a novel series of water-soluble PDE4 inhibitors. Our studies led to the discovery of coumarin 18, whic
