158440-80-3

Upstream product

• 1127955-74-1 2-bromobenzyl 4-(dimethylamino)phenyl ketone 
• 39195-66-9 2-(4-chlorophenyl)benzofuran 
• 68-12-2 N,N-dimethyl-formamide 
• 533-58-4 2-Iodophenol 
• 17573-94-3 4-ethynyl-N,N-dimethylaniline 

Relevant academic research and scientific papers

Accessing a Biologically Relevant Benzofuran Skeleton by a One-Pot Tandem Heck Alkynylation/Cyclization Reaction Using Well-Defined Palladium N-Heterocyclic Carbene Complexes

Well-defined palladium N-heterocyclic carbene (NHC) complexes were employed in the one-pot tandem Heck alkynylation/cyclization sequence for preparing biologically relevant benzofuran compounds under copper-free conditions in a time-efficient step-reduced

Nickel-Catalyzed Amination of Aryl Chlorides with Amides

A nickel-catalyzed amination of aryl chlorides with diverse amides via C-N bond cleavage has been realized under mild conditions. A broad substrate scope with excellent functional group tolerance at a low catalyst loading makes the protocol powerful for synthesizing various aromatic amines. The aryl chlorides could selectively couple to the amino fragments rather than the carbonyl moieties of amides. Our protocol complements the conventional amination of aryl chlorides and expands the usage of inactive amides.

One-Pot preparation of 2-arylbenzofurans from oximes with diaryliodonium triflate

A variety of 2-arylbenzofurans were obtained in good yields by the O-arylation of oximes with diaryliodonium triflates, followed by the treatment with HCl in dioxane under warming conditions through the [3,3]-sigmatropic reaction. The present reaction is one-pot transition metal-free method for the preparation of various 2-arylbenzofurans from oximes, which are easily available from the reaction of alkyl aryl ketones with hydroxylamine.

Impregnated copper or palladium-copper on magnetite as catalysts for the domino and stepwise Sonogashira-cyclization processes: A straightforward synthesis of benzo[b]furans and indoles

An impregnated copper on magnetite catalyst is a versatile system for different domino Sonogashira-cyclization processes between 2-iodophenol and different alkynes to give the corresponding substituted benzo[b]furans. The catalyst could be recovered ten times without losing its activity. The related process using 2-iodoaniline was, however, better catalyzed by mixed palladium-copper on magnetite giving exclusively, in this case, the products arising from the Sonogashira coupling. The cyclization to the corresponding substituted indoles could be easily and quantitatively performed by zinc bromide treatment. This catalyst avoids the use of any type of expensive and difficult to handle organic ligand, showing excellent yields, under mild reaction conditions. The catalyst is very easy to remove from the reaction medium, just by using a simple magnet.

A convenient two-step synthesis of 2-arylbenzofurans

A novel and convenient two-step synthesis of 2-arylbenzofurans is described which proceeds via a selective cross-pinacol-type coupling between a salicylaldehyde and an aromatic aldehyde, followed by an acid-promoted cyclization. One advantage of this method is that separation of the three possible pinacol products that can form during the cross-coupling is not necessary. This method is also applied to the synthesis of the 2-arylbenzofuran-containing natural product, homoegonol.

Synthesis of benzo[b]furans by palladium-NHC catalyzed ring closure of o-bromobenzyl ketones

The palladium-catalyzed ring closure of aryl o-bromobenzyl ketones, easily accessible from aromatic aldehydes and 2- bromobenzyl bromide, provides a straightforward route to 2-aryl- benzofurans. A study of the ring closure revealed that a heterocyclic car

Benzofuran derivatives and the use thereof as stabilizers against UV radiations

Compounds of the general formula I STR1 wherein R--R4 are as defined in the description, have stabilizing activity against UV radiation and are useful in cosmetics and dermatology.

Benzofuran derivatives and the use thereof as stabilizers against UV radiations

Compounds of the general formula I wherein R-R4 are as defined in the description, have stabilizing activity against UV radiation and are useful in cosmetics and dermatology.