1584686-28-1

Basic information

• Product Name: tert-butyl 6-(benzyloxy)nicotinate
• Synonyms: tert-butyl 6-(benzyloxy)nicotinate
• CAS NO: 1584686-28-1
• Molecular Weight: 285.343
• Mol File: 1584686-28-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 6-(benzyloxy)nicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 6-(benzyloxy)nicotinate(1584686-28-1)
• EPA Substance Registry System: tert-butyl 6-(benzyloxy)nicotinate(1584686-28-1)

Safety Data

• Hazardous Substances Data: 1584686-28-1(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 832735-54-3 2-(benzyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 

Relevant articles and documents

A larene/ fragrant mixedsurrounds uncle butanol method for preparing ester compounds

The invention discloses a preparation method of an aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound. The preparation method of the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound comprises the following steps of: firstly, under stirring condition, adding aromatic heterocycle borate compound or aromatic ring boric acid compound and di-tert-butyl dicarbonate ester into a solvent, and then adding a palladium catalyst and a ligand, so that a mixture A is obtained; secondly, heating the mixture A for carrying out reaction, and then cooling to room temperature, so that a mixture B is obtained; thirdly, diluting the mixture B with ethyl acetate, then filtering the diluted mixture B with diatomite, collecting filtrate, concentrating, and carrying out spin drying, so that the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound is obtained. The preparation method of the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound has the advantages that alkoxycarbonylation reaction on an aromatic heterocycle borate compound or aromatic ring boric acid compound is realized, and the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound is directly generated; raw materials are non-toxic, inexpensive and available; a catalytic system is low in cost and has good stability and broad applicability; reaction conditions are mild, safety is high, and control is easy; a technology is simple, operation is easy, environmental friendliness is realized, and specificity is strong, so that the preparation method of the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound is applicable to industrialized production.

Preparation of tert-butyl esters via Pd-catalyzed tert-butoxycarbonylation of (hetero)aryl boronic acid derivatives

A novel protocol to synthesize tert-butyl esters from boronic acids or boronic acid pinacol esters and di-t-butyl dicarbonate has been successfully achieved. The cross-coupling reactions can produce up to 94% yields by using palladium acetate and triphenylphosphine as catalyst system, dioxane as a solvent. Moreover, a wide range of substrates including benzenes, pyridines, and quinolines boronic acids or boronic acid pinacol esters can fit with this system as well.