1584701-82-5Relevant academic research and scientific papers
Domino asymmetric conjugate addition-conjugate addition
Germain, Nicolas,Schlaefli, Doriane,Chellat, Mathieu,Rosset, Stephane,Alexakis, Alexandre
, p. 2006 - 2009 (2014/05/06)
Enantioenriched Al-, Mg-, and Zn-enolates undergo electrophilic trapping by nitroolefins and vinylsulfones to afford 1,4-diketones and 2- (bis(phenylsulfonyl)ethyl)ketones in good yield and excellent diastereoselectivity. A one-pot preparation of indenes and enantiopure syntheses of tetrahydrobenzofurans, tetrahydrobenzopyrroles, and azulenes are disclosed. A site-selective two-step sequence of three conjugate additions is also demonstrated.
