1584706-72-8Relevant academic research and scientific papers
Triazole-tailored guanosine dinucleosides as biomimetic ion channels to modulate transmembrane potential
Kumar, Y. Pavan,Das, Rabindra Nath,Kumar, Sonu,Schütte, Ole Mathis,Steinem, Claudia,Dash, Jyotirmayee
, p. 3023 - 3028 (2014)
A click ion channel platform has been established by employing a clickable guanosine azide or alkyne with covalent spacers. The resulting guanosine derivatives modulated the traffic of ions across the phospholipid bilayer, exhibiting a variation in conductance spanning three orders of magnitude (pS to nS). F?rster resonance energy transfer studies of the dansyl fluorophore with the membrane binding fluorophore Nile red revealed that the dansyl fluorophore is deeply embedded in the phospholipid bilayer. Complementary cytosine can inhibit the conductance of the supramolecular guanosine channels in the phospholipid bilayers. Coming through: A click ion-channel platform was established by employing a clickable guanosine azide or alkyne with covalent spacers. The guanosine derivatives modulated the traffic of ions across the phospholipid bilayer. FRET studies of the dansyl fluorophore with the membrane-binding fluorophore Nile red revealed that the dansyl fluorophore is deeply embedded in the phospholipid bilayer (see figure).
