158474-18-1

Basic information

• Product Name: (4-(dimethylamino)phenyl)(3-(trifluoromethyl)phenyl)methanone
• CAS NO: 158474-18-1
• Molecular Weight: 293.288
• Mol File: 158474-18-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4-(dimethylamino)phenyl)(3-(trifluoromethyl)phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-(dimethylamino)phenyl)(3-(trifluoromethyl)phenyl)methanone(158474-18-1)
• EPA Substance Registry System: (4-(dimethylamino)phenyl)(3-(trifluoromethyl)phenyl)methanone(158474-18-1)

Safety Data

• Hazardous Substances Data: 158474-18-1(Hazardous Substances Data)

Upstream product

• 24167-52-0 N,N-dimethyl-3-chlorobenzamide 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 
• 121-69-7 N,N-dimethyl-aniline 

Downstream Products

• 158474-29-4 1-<4-(dimethylamino)phenyl>-3-phenyl-1-<3-(trifluoromethyl)phenyl>-2-propyn-1-ol 

Relevant articles and documents

One-pot, modular approach to functionalized ketones via nucleophilic addition/Buchwald-Hartwig amination strategy

A general one-pot procedure for the 1,2-addition of organolithium reagents to amides followed by the Buchwald-Hartwig amination with in situ released lithium amides is presented. In this work amides are used as masked ketones, revealed by the addition of organolithium reagents which generates a lithium amide, suitable for subsequent Buchwald-Hartwig coupling in the presence of a palladium catalyst. This methodology allows for rapid, efficient and atom economic synthesis of aminoarylketones in good yields.