158474-18-1Relevant academic research and scientific papers
One-pot, modular approach to functionalized ketones via nucleophilic addition/Buchwald-Hartwig amination strategy
De Jong, Jorn,Heijnen, Dorus,Helbert, Hugo,Feringa, Ben L.
supporting information, p. 2908 - 2911 (2019/03/17)
A general one-pot procedure for the 1,2-addition of organolithium reagents to amides followed by the Buchwald-Hartwig amination with in situ released lithium amides is presented. In this work amides are used as masked ketones, revealed by the addition of organolithium reagents which generates a lithium amide, suitable for subsequent Buchwald-Hartwig coupling in the presence of a palladium catalyst. This methodology allows for rapid, efficient and atom economic synthesis of aminoarylketones in good yields.
Synthesis, Absorption Spectra, and Photostability of Triarylmethane Dye Ethynylogues Containing Trifluoromethyl Group(s)
Muramatsu, Hiroshige,Okumura, Akinori,Shibata, Katsuyoshi,Matsui, Masaki
, p. 1627 - 1632 (2007/10/02)
Triarylmethane dye ethynylogues 7'-11' containing trifluoromethyl group(s) are synthesized in moderate to good yields by treating 1,1,3-triaryl-2-propyn-1-ols, prepared from diaryl ketones and lithium arylacetylides bearing trifluoromethyl group(s), with
