1584740-52-2Relevant academic research and scientific papers
Regioselective nucleophilic addition of organometallic reagents to 3-geminal bis(silyl) N-acyl pyridinium
Wu, Ya,Li, Linjie,Li, Hongze,Gao, Lu,Xie, Hengmu,Zhang, Zhigao,Su, Zhishan,Hu, Changwei,Song, Zhenlei
, p. 1880 - 1883 (2014/05/06)
A regioselective nucleophilic addition to 3-geminal bis(silyl) N-acyl pyridinium has been described. Geminal bis(silane) shows contrasting roles that lead to different regioselectivities for the addition of different nucleophiles: its steric effect dominates to favor 1,6-addition of alkyl, vinyl, and aryl organometallic reagents; its directing effect dominates to favor 1,2-addition of less sterically demanding alkynyl Grignard reagents.
