158479-06-2Relevant academic research and scientific papers
SYNTHESIS OF (+/-)-4-AMINO-1,3,4,5-TETRAHYDROBENZINDOLE-4-CARBOXYLIC ACID, (+/-)-4-N,N-DIPROPYLAMINO-4-HYDROXYMETHYL- AND (+/-)-4-PROPYLOXY-1,3,4,5-TETRAHYDROBENZINDOLE
Somei, Masanori,Aoki, Naokatsu,Nakagawa, Kyoko
, p. 1479 - 1482 (1994)
Simple syntheses of the title compounds are reported starting from indole-3-carboxaldehyde.
Syntheses of 4-amino-, 4-hydroxy-, and 4-nitro-1,3,4,5-tetrahydrobenz[cd]indoles and its bromination
Nakagawa, Kyoko,Aoki, Naokatsu,Mukaiyama, Harunobu,Somei, Masanori
, p. 493 - 520 (2016/11/01)
Simple synthetic method for 4-nitro-1,3,4,5-tetrahydrobenz[cd]indole (6) is established from indole-3-carboxaldehyde (7). With 6 in hand, various derivatives of 4-amino-, 4-hydroxy- and 4-amino-4-hydroxymethyl-1,3,4,5-tetrahydrobenz[cd]indoles become readily available. Bromination of 6 afforded useful building blocks for further manipulation. Successful optical resolution of 6 by chiral column chromatography is also reported.
