158502-57-9Relevant academic research and scientific papers
Synthesis of multi-functional alkenes via Wittig reaction with a new-type of phosphorus ylides
Tsai, Yi-Ling,Syu, Siang-En,Yang, Shu-Mei,Das, Utpal,Fan, Yu-Shiou,Lee, Chia-Jui,Lin, Wenwei
, p. 5038 - 5045 (2014/07/08)
A Bu3P-mediated mild and efficient synthesis of multi-functional alkenes has been described starting from substituted acrylate with aldehydes. In situ generated zwitterionic intermediates underwent proton-exchange to afford ylide intermediates, which were trapped by corresponding aldehydes providing the products in up to 92% yield with complete E-stereoselectivity. Further derivatization of the products was performed to furnish functional pyridazinones.
Synthesis of multi-functional alkenes via Wittig reaction with a new-type of phosphorus ylides
Tsai, Yi-Ling,Syu, Siang-En,Yang, Shu-Mei,Das, Utpal,Fan, Yu-Shiou,Lee, Chia-Jui,Lin, Wenwei
, p. 5038 - 5045 (2014/12/10)
A Bu3P-mediated mild and efficient synthesis of multi-functional alkenes has been described starting from substituted acrylate with aldehydes. In situ generated zwitterionic intermediates underwent proton-exchange to afford ylide intermediates, which were trapped by corresponding aldehydes providing the products in up to 92% yield with complete E-stereoselectivity. Further derivatization of the products was performed to furnish functional pyridazinones.
Synthesis and Chemistry of 4-Aroyl-3-oxo- and 3-Chloropyridazine Derivatives
Shalaby, Alyaa A.,Youssef, Ali M.,Youssef, Wael A.,Shams, Nabil A.
, p. 477 - 480 (2007/10/03)
4H,5H-6-Phenyl (1a) and 6-p-phenoxyphenyl (1b) pyridazin-3(2H)-ones were reacted with aromatic aldehydes to give 4-arylmethylpyridazin-3(2H)-ones (2a-g).Oxidation of (2a-g) with various oxidising agents (selenium dioxide in ethanol or chromium trioxide in acetic acid) gave 4-aroyl-6-arylpyridazin-3(2H)-ones (3a-g).Chlorination of (3a-g) with phosphorus oxychloride afforded 4-aroyl-6-aryl-3-chloropyridazine (4a-g). 1H-3-Aryl-5-phenylpyrazolopyridazines (5a-d) were obtained by heating (4a-d) with excess hydrazine hydrate.Hydroxyamination of (3e-g) with hydroxylamine gave aryl-4(6-p-phenoxyphenyl-2,3-dihydro-3-oxo)pyridazinyl oxime (6a-c).Silylation of oximes (6b and 6c) gave (7a and 7b) as acyclic compound instead of the expected seven-membered-ring compound (8).
