15851-63-5

Usage

General Description

8-hydroxy-7-nitroquinoline-5-sulfonic acid, also known as 8-hydroxyquinoline-7-sulfonic acid, is a chemical compound with the molecular formula C9H6N2O6S. It is a bright yellow solid that is commonly used as a pH indicator, and its sulfonic acid group allows it to be highly water-soluble. 8-hydroxy-7-nitroquinoline-5-sulfonic acid is also used in the manufacture of dyes, drugs, and insecticides, and it has been studied for its potential anticancer and antimicrobial properties. Additionally, it is often employed in various analytical and biochemical applications due to its ability to chelate metal ions such as zinc, copper, and mercury.

Upstream product

• 84-88-8 8-quinolinol-5-sulfonic acid 
• 148-24-3 8-quinolinol 
• 5263-74-1 7-Nitroso-8-hydroxyquinoline-5-sulphonic acid 

Downstream Products

• 1084-32-8 5,7-dinitro-quinolin-8-ol 
• 15851-62-4 7-Amino-8-hydroxy-chinolin-5-sulfonsaeure 

Relevant academic research and scientific papers

8-hydroxy-7-nitroquinoline-5-sulfonic acid monohydrate

The title compound, C9H6N2O6S.H2O, is zwitterionic (i.e. 8-hydroxy-7-nitroquinolinium-5-sulfonate monohydrate) with a deprotonated sulfonic group and a protonated quinoline N atom which interacts with the hydroxy O atom. The H atom of the hydroxy group is distal to the N atom and is involved in an interaction with an O atom of the nitro group, which is oriented at 32.2(1)° with respect to the quinoline ring system.

Study on Relationship Between Fluorescence Properties and Structure of Substituted 8-Hydroxyquinoline Zinc Complexes

Organic light-emitting diodes (OLEDs) produced from 8-hydroxyquinoline metal complexes play a vital role in modern electroluminescent devices. In this manuscript, a series of 8-hydroxyquinoline derivatives were synthesized by different methods and their corresponding zinc metal complexes were prepared. The UV and fluorescence properties of the complexes were measured aiming to understand the effect of substituents at the quinoline ring on the fluorescence properties of the complexes. When the C-5 of 8-hydroxyquinoline was replaced by halogen group, the fluorescence emission wavelengths had been red-shifted, at the same time, blue-shifted of fluorescence emission wavelength was observed when the C-5 position of 8-hydroxyquinoline was substituted by electron-withdrawing group. When the C-4 position of 8-hydroxyquinolie was substituted by methyl or the C-5 position was substituted by sulfonic acid group, the corresponding zinc complexes had higher fluorescence intensity than 8-hydroxyquinolie zinc.

Investigating the activity spectrum for Ring-Substituted 8-Hydroxyquinolines

In this study, a series of fourteen ring-substituted 8-hydroxyquinoline derivatives were prepared. The synthesis procedures are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity. They were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than the standards isoniazid or fluconazole. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed.

DISULFONAMIDES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided compounds of formula (I), wherein the A ring, X1, X2, R1, R2, Cx, Qy, T1 and T2 have meanings given in the description, and pharmaceutically-acceptab

Protonation of Oxines: Failure of Taft Equation

Protonation of 8-hydroxyquinoline-5-sulfonic acid and it's 7-bromo, 7-iodo, 7-nitro and 7-nitroso derivatives have been studied by spectrophotometry and potentiometry.Attempts to apply the Taft equation for linear free energy correlations between protonation constants and Taft substituent constants for ortho substituents were unsuccessful.Better correlation was obtained with the Hammett substituent constants.