15851-88-4Relevant articles and documents
Microwave-associate synthesis of Co3O4 nanoparticles as an effcient nanocatalyst for the synthesis of arylidene barbituric and Meldrum's acid derivatives in green media
Yahyazadehfar, Mahdieh,Sheikhhosseini, Enayatollah,Ahmadi, Sayed Ali,Ghazanfari, Dadkhoda
, (2019/08/02)
In this study, Co3O4 nanocatalysts were constructed in environmentally appropriate conditions using controlled, effective, and facile microwave method. The final nanostructures were characterized by SEM, XRD, and TEM analyses. The products had a small size distribution, homogeneous morphology, and crystallographic structures associated with the formation of Co3O4 nanostructures. Moreover, EDS mapping analysis confirmed the existence of Co and O elements in the final structure, and the magnetic properties of the samples were investigated by VSM. The application of this nanostructure in a catalytic process was further examined, and the results suggested that it could be used as a novel candidate for the synthesis of arylidene barbituric and Meldrum,s acid through Knoevenagel condensation of aldehydes by barbituric and Meldrum,s acid in aqueous media. The high yield of these nanocatalysts would be justified by the nature of the nanostructure as well as the experimental procedure developed in this study, which affected the physicochemical features of the products.
A transition metal free expedient approach for the C[dbnd]C bond cleavage of arylidene Meldrum's acid and malononitrile derivatives
Suresh, Muthiah,Kumari, Anusueya,Singh, Raj Bahadur
, (2019/09/10)
A transition metal free expedient approach for the C[dbnd]C bond cleavage of electron deficient alkenes such as arylidene Meldrum's acid and malononitrile derivatives are discussed. The C[dbnd]C bond of these compound were cleaved to benzoic acid in good yield at high temperature. Most importantly, with oxone in CH3CN/H2O at 45 °C or m-CPBA in DCM or NaClO2 in THF/H2O or PIDA in THF at room temperature furnished benzaldehyde derivatives selectively in excellent yields.
Water assisted and choline chloride-dimethylurea deep eutectic salts as catalyst towards the attractive reaction of indole, benzaldehyde, and malononitrile
Ruan, Hongli,Lv, Yue,Yu, Shijun,Lv, Chengwei,An, Yue
, p. 1266 - 1274 (2018/08/06)
The condensation of indole, benzaldehyde, and malononitrile was relatively rigorous compared with other Yonemitsu type reaction. We described a strategy using catalytic amount of choline chloride-dimethylurea deep eutectic salts as cheap and safe accelerator. We also found that introducing right amount of water in reaction system was crucial. This method tolerates variations in all three components to get desired 3-substituted indoles in satisfactory yields.
Synthesis of new guanidium-meldrum acid zwitterionic salts and dynamic NMR study of rotational energy barrier around C-NH bond of guanidine moiety
Aminkhani, Ali
, p. 1791 - 1797 (2015/04/27)
Synthesis of the Guanidium-Meldrum acid zwitterionic salts was developed through a three component reaction of 2, 2-dimethyl-1, 3-dioxane-4, 6-dione (Meldrum acid), aromatic aldehydes and N, N, N', N'- Tetramethyl-guanidine in benzen at room temperature.
Synthesis of 5-arylidene-2,2-dimethyl-1,3-dioxane-4,6-diones and coumarin-3-carboxylic acids via reaction of nitrones and Meldrum's acid
Kumar, Dhruva,Suresh,Sandhu, Jagir S.
, p. 1157 - 1160 (2013/09/24)
A variety of nitrones have been synthesized and reacted with Meldrum's acid without the aid of any catalysts. Selectively, 5- arylidene-2,2-dimethyl-1,3- dioxane-4,6-diones have been obtained with excellent yields under environmentally benign reaction conditions. Whereas, nitrone of salisylaldehydes with Meldrum's acid afford cyclized products i.e. coumarin-3- carboxylic acids.
Synthesis of a new urea derivative: A dual-functional organocatalyst for Knoevenagel condensation in water
Le, Wen-Jun,Lu, Hong-Fei,Zhou, Jun-Tao,Cheng, He-Long,Gao, Yu-Hua
, p. 5370 - 5373 (2013/09/12)
A phenylalanine-urea compound-catalyzed Knoevenagel condensation in water is reported. Various aldehydes and active methylene compounds undergo condensation at room temperature to give the desired products in high yields. The mechanism of the condensation of aldehydes with Meldrum's acid catalyzed by the novel urea derivative is also disclosed.
Pseudo five-component process for the synthesis of functionalized tricarboxamides using CuI nanoparticles as reusable catalyst
Ziarati, Abolfazl,Safaei-Ghomi, Javad,Rohani, Sahar
, p. 195 - 198 (2013/06/26)
An efficient and multicomponent method has been developed for the synthesis of functionalized tricarboxamides at room temperature using CuI nanoparticles as catalyst. This method involved five-component coupling reactions of Meldrum's acid, isocyanides wi
Discovery and preliminary SAR of 5-arylidene-2,2-dimethyl-1,3-dioxane-4,6- diones as platelet aggregation inhibitors
El Maatougui, Abdelaziz,Azuaje, Jhonny,Coelho, Alberto,Yaziji, Vicente,Carbajales, Carlos,Sotelo, Eddy,Lopez, Carmen,Cano, Ernesto,Yanez, Matilde
, p. 551 - 554,4 (2020/08/31)
We herein document the discovery of 5-arylidene-2,2-dimethyl-1,3-dioxane-4, 6-diones as a novel family of platelet aggregation inhibitors. The preliminary optimization study enabled us to establish the most salient features of the structure-activity relat
Facile Knoevenagel and domino Knoevenagel/Michael reactions using gel-entrapped base catalysts
Shinde, Shital,Rashinkar, Gajanan,Kumbhar, Arjun,Kamble, Santosh,Salunkhe, Rajashri
experimental part, p. 1943 - 1951 (2012/01/04)
An efficient method for Knoevenagel condensation of arenecarbaldehydes with active methylene compounds such as barbituric acid and Meldrum's acid in the presence of gel-entrapped base catalysts is reported. The method has been extended to the one-pot synthesis of arylmethylene-bis[3-hydroxycyclohex-2-en-1- one] derivatives from dimedone (=5,5-dimethylcyclohexane-1,3-dione) and arenecarbaldehydes by using domino Knoevenagel/Michael reaction sequence. Copyright
Knoevenagel condensation of aldehydes with Meldrum's acid in ionic liquids
Tahmassebi, Daryoush,Wilson, Levi J. A.,Kieser, Jerod M.
experimental part, p. 2605 - 2613 (2009/12/04)
The Knoevenagel condensation of Meldrum's acid with aromatic aldehydes proceeded efficiently in the recyclable ionic liquid [bmim]BF4 at room temperature in the presence of catalytic amounts of piperidine.
