158580-95-1

Usage

Uses

Used in Pharmaceutical Industry:
6,7-DIFLUOROINDOLINE-2,3-DIONE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its unique properties allow for the creation of new drug candidates with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical sector, 6,7-DIFLUOROINDOLINE-2,3-DIONE is utilized as an intermediate in the production of agrochemicals, contributing to the development of new pesticides or other agricultural chemicals that can improve crop protection and yield.
Used in Organic Chemistry Research:
6,7-DIFLUOROINDOLINE-2,3-DIONE is used as a versatile compound in organic chemistry research for its potential to undergo diverse chemical reactions. This makes it an invaluable tool for synthetic chemists exploring new methods of synthesis and the creation of novel organic molecules.
Used in the Synthesis of Heterocyclic Compounds:
6,7-DIFLUOROINDOLINE-2,3-DIONE is employed as a building block in the synthesis of heterocyclic compounds, which are important in various areas of chemistry, including the development of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in the Development of Biologically Active Compounds:
Due to its reactivity and structural attributes, 6,7-DIFLUOROINDOLINE-2,3-DIONE is used in the development of biologically active compounds, which may have applications in medicine, biotechnology, and other life sciences.

InChI:InChI=1/C8H3F2NO2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12/h1-2H,(H,11,12,13)

Upstream product

• 4519-40-8 2,3-difluoroanilline 
• 75-87-6 chloral 
• 170108-12-0 N-(2,3-difluorophenyl)-2-(hydroxyimino)acetamide 

Downstream Products

• 158580-94-0 2-amino-3,4-difluorobenzoic acid 
• 1314008-27-9 (2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol) 
• 1491155-36-2 3-[4-(dimethylamino)phenyl]-6,7-difluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one 
• 1491155-51-1 3-(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoro-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one 
• 1491155-60-2 3-(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoro-3-(4-hydroxyphenyl)-1,3-dihydro-2H-indol-2-one 
• 271780-84-8 6,7-difluoro-1H-indole 
• 1584229-89-9 3,3-bis(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoroindolin-2-one 
• 1314012-51-5 1-[2-fluoro-6-(7,8-difluoro-2-methylquinolin-3-yloxy)-phenyl]-ethanone 
• 1073261-97-8 (RS)-3-cyclohexyl-6,7-difluoro-3-hydroxyindolin-2-one 
• 1247028-68-7 (RS)-3-(4-ethoxyphenyl)-6,7-difluoro-3-hydroxyindolin-2-one 
• 1247028-64-3 (RS)-6,7-difluoro-3-(4-fluorophenyl)-3-hydroxyindolin-2-one 
• 867155-08-6 (RS)-6,7-difluoro-3-hydroxy-3-p-tolylindolin-2-one 
• 867155-10-0 6,7-difluoro-3-hydroxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one 
• 1247028-63-2 (RS)-6,7-difluoro-3-hydroxy-3-phenylindolin-2-one 

Relevant academic research and scientific papers

Pyrimidine amine compound, and preparation method and application thereof

The invention discloses a polycyclic compound, and a preparation method and an application thereof. The invention provides the polycyclic compound represented by formula I, or a pharmaceutically acceptable salt thereof. The compound has a relatively good inhibition effect on CDK7.

Heteroaromatic nitrile compound and application thereof

The invention discloses a heteroaromatic nitrile compound and application thereof. The invention provides a heteroaromatic nitrile compound shown as formula I or a pharmaceutically acceptable salt thereof. The compound has a good inhibition effect on CDK7.

NITROGENATED HETEROCYCLIC COMPOUND AND AGRICULTURAL OR HORTICULTURAL FUNGICIDE

An agricultural or horticultural fungicide contains as an active ingredient thereof at least one compound selected from the group consisting of nitrogenated heterocyclic compounds represented by formula (I) (wherein, R represents a group represented by CR

3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION

Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using diaryloxindole compounds are described.

Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors

The growing recognition of inhibition of translation initiation as a new and promising paradigm for mechanism-based anti-cancer therapeutics is driving the development of potent, specific, and druggable inhibitors. The 3,3-diaryloxindoles were recently reported as potential inhibitors of the eIF2·GTP·Met-tRNAiMet ternary complex assembly and 3-{5-tert-butyl-2-hydroxyphenyl}-3-phenyl-1,3-dihydro-2H-indol-2- one #1181 was identified as the prototypic agent of this chemotype. Herein, we report our continuous effort to further develop this chemotype by exploring the structural latitude toward different polar and hydrophobic substitutions. Many of the novel compounds are more potent than the parent compound in the dual luciferase ternary complex reporter assay, activate downstream effectors of reduced ternary complex abundance, and inhibit cancer cell proliferation in the low μM range. Moreover, some of these compounds are decorated with substituents that are known to endow favorable physicochemical properties and as such are good candidates for evaluation in animal models of human cancer.

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND AGRICULTURAL FUNGICIDE

Provided is an agricultural fungicide that contains at least one selected from the group consisting of a novel nitrogen-containing heterocyclic compound represented by Formula (I), a salt thereof, or an N-oxide compound thereof. In Formula (I), R represen

4- [HETEROCYCLYL-METHYL] -8-FLUORO-QUINOLIN-2-ONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS

Novel compounds of formulae (II, III) and pharmaceutical compositions have been found to inhibit inducible NOS synthase wherein: R4, R5, R6 and R7 are independently selected from the group consisting of hydrogen, lower alkyl, and halogen; and, R8 has the structure whrein X1, X2, X3, X4, X5, X6, R9, R13, R14 and n are as described herein.