158580-95-1

Basic information

• Product Name: 6,7-DIFLUOROINDOLINE-2,3-DIONE
• Synonyms: 6,7-DIFLUOROINDOLINE-2,3-DIONE;6,7-difluoro-2,3-dihydro-1H-indole-2,3-dione;6,7-Difluoro-1H-indole-2,3-dione;1H-Indole-2,3-dione,6,7-difluoro-;6,7-Difluoro-1H-indole-2,3-dione(WXFC0377)
• CAS NO: 158580-95-1
• Molecular Formula: C₈H₃F₂NO₂
• Molecular Weight: 183.11
• Mol File: 158580-95-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.579g/cm³
• Refractive Index: 1.558
• PKA: 7.25±0.20(Predicted)
• CAS DataBase Reference: 6,7-DIFLUOROINDOLINE-2,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DIFLUOROINDOLINE-2,3-DIONE(158580-95-1)
• EPA Substance Registry System: 6,7-DIFLUOROINDOLINE-2,3-DIONE(158580-95-1)

Safety Data

• Hazardous Substances Data: 158580-95-1(Hazardous Substances Data)

Usage

General Description

6,7-DIFLUOROINDOLINE-2,3-DIONE, also known as difluoroindole-2,3-dione, is a chemical compound with the molecular formula C8H4F2N2O2. It is a yellow solid that is mainly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 6,7-DIFLUOROINDOLINE-2,3-DIONE is an important building block in organic chemistry and is often utilized in the preparation of various heterocyclic compounds and complex organic molecules. 6,7-DIFLUOROINDOLINE-2,3-DIONE has attractive properties, including its ability to undergo diverse chemical reactions, making it a valuable tool for synthetic chemists in the development of new drugs and other biologically active compounds. Moreover, its unique structure and reactivity make it a versatile and valuable compound in the field of organic chemistry.

InChI:InChI=1/C8H3F2NO2/c9-4-2-1-3-6(5(4)10)11-8(13)7(3)12/h1-2H,(H,11,12,13)

Upstream product

• 4519-40-8 2,3-difluoroanilline 
• 75-87-6 chloral 
• 170108-12-0 N-(2,3-difluorophenyl)-2-(hydroxyimino)acetamide 

Downstream Products

• 1247028-71-2 (RS)-6,7-difluoro-3-hydroxy-3-(3-methoxyphenyl)indolin-2-one 
• 1247028-73-4 (RS)-3-benzyl-6,7-difluoro-3-hydroxyindolin-2-one 
• 1073261-91-2 (RS)-3-(cyclohexylmethyl)-6,7-difluoro-3-hydroxy-indolin-2-one 
• 1247028-69-8 (RS)-6,7-difluoro-3-hydroxy-3-(4-propoxyphenyl)indolin-2-one 
• 1247028-70-1 (RS)-6,7-difluoro-3-hydroxy-3-[4-(pentyloxy)phenyl]-indolin-2-one 
• 1073262-08-4 (RS)-3-(3,4-difluorophenyl)-6,7-difluoro-3-hydroxyindolin-2-one 
• 1247028-63-2 (RS)-6,7-difluoro-3-hydroxy-3-phenylindolin-2-one 
• 867155-10-0 6,7-difluoro-3-hydroxy-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one 
• 1314008-27-9 (2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol) 
• 1491155-36-2 3-[4-(dimethylamino)phenyl]-6,7-difluoro-3-hydroxy-1,3-dihydro-2H-indol-2-one 
• 1491155-51-1 3-(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoro-3-(4-methoxyphenyl)-1,3-dihydro-2H-indol-2-one 
• 1491155-60-2 3-(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoro-3-(4-hydroxyphenyl)-1,3-dihydro-2H-indol-2-one 
• 271780-84-8 6,7-difluoro-1H-indole 
• 1584229-89-9 3,3-bis(5-tert-butyl-2-hydroxyphenyl)-6,7-difluoroindolin-2-one 

Relevant articles and documents

Pyrimidine amine compound, and preparation method and application thereof

The invention discloses a polycyclic compound, and a preparation method and an application thereof. The invention provides the polycyclic compound represented by formula I, or a pharmaceutically acceptable salt thereof. The compound has a relatively good inhibition effect on CDK7.

NITROGENATED HETEROCYCLIC COMPOUND AND AGRICULTURAL OR HORTICULTURAL FUNGICIDE

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Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors

The growing recognition of inhibition of translation initiation as a new and promising paradigm for mechanism-based anti-cancer therapeutics is driving the development of potent, specific, and druggable inhibitors. The 3,3-diaryloxindoles were recently reported as potential inhibitors of the eIF2·GTP·Met-tRNAiMet ternary complex assembly and 3-{5-tert-butyl-2-hydroxyphenyl}-3-phenyl-1,3-dihydro-2H-indol-2- one #1181 was identified as the prototypic agent of this chemotype. Herein, we report our continuous effort to further develop this chemotype by exploring the structural latitude toward different polar and hydrophobic substitutions. Many of the novel compounds are more potent than the parent compound in the dual luciferase ternary complex reporter assay, activate downstream effectors of reduced ternary complex abundance, and inhibit cancer cell proliferation in the low μM range. Moreover, some of these compounds are decorated with substituents that are known to endow favorable physicochemical properties and as such are good candidates for evaluation in animal models of human cancer.