158585-52-5

Upstream product

• 120-72-9 indole 
• 80472-59-9 S-(4-methoxyphenyl) (4-methylbenzene)thiosulfonate 
• 1950-68-1 4-methoxybenzenesulfonyl hydrazide 
• 696-63-9 4-Methoxybenzenethiol 
• 5335-87-5 4,4'-dimethoxyphenyl disulfide 

Downstream Products

• 158585-54-7 1-methyl-2,3-bis<(4-methoxyphenyl)thio>indole 
• 139461-66-8 2-<(4-methoxyphenyl)thio>indole 

Relevant academic research and scientific papers

Cu-catalysed direct bis-thiolation of benzoheterocycles with arylsulfonyl hydrazides

A series of bis-arylsulfenylated indoles (10), benzofurans (3), and benzothiophenes (3) and of monosulfenylated indoles (5), 12 of which are novel, were prepared in good yields via a Cu-catalysed direct sulfenylation of benzoheterocycles with arylsulfonyl hydrazides. Sulfonothioates are probably the major thiolated intermediates in this transformation.

Metal free sulfenylation and bis-sulfenylation of indoles: Persulfate mediated synthesis

A method which avoids metal and halogen for the synthesis of 3-arylthioindoles from indoles and diaryl disulfides using ammonium persulfate in methanol has been presented. Moreover, double C-H sulfenylation of indoles at 2 and 3-positions has also been ac

Nonreductive Desulfenylation of 3-Indolyl Sulfides. Improved Syntheses of 2-Substituted Indoles and 2-Indolyl Sulfides

Desulfenylation of 3-indolyl sulfides to the corresponding 3-unsubstituted indoles is usually carried out under reductive conditions, thus accommodating only substituents which are resistant to reduction.We have developed a nonreductive procedure for removal of a sulfide at the 3-position of indoles, using trifluoroacetic acid in the presence of a thiol as trapping agent, which is compatible with a large array of functionalities on the indole ring.In addition, the desulfenylation occurs selectively at the 3-position of the indole, and sulfide groups at other positions of the molecule remain untouched.Thus, indole 2,3-bis-sulfides are selectively desulfenylated at the 3-position, affording 3-unsubstituted 2-indolyl sulfides.This methodology broadens the use of sulfide as a protecting group for the 3-position of indoles.