1585969-79-4

Basic information

• Product Name: 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoic acid
• Synonyms: 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoic acid
• CAS NO: 1585969-79-4
• Molecular Weight: 396.24
• Mol File: 1585969-79-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoic acid(1585969-79-4)
• EPA Substance Registry System: 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoic acid(1585969-79-4)

Safety Data

• Hazardous Substances Data: 1585969-79-4(Hazardous Substances Data)

Upstream product

• 1585969-87-4 methyl 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoate 
• 46064-79-3 2-bromo-5-methoxycarbonylaniline 
• 2840-29-1 3-amino-4-bromobenzoic acid 

Relevant articles and documents

Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections

Targeting PqsD is a promising novel approach to disrupt bacterial cell-to-cell-communication in Pseudomonas aeruginosa. In search of selective PqsD inhibitors, two series of benzamidobenzoic acids - one published as RNAP inhibitors and the other as PqsD inhibitors - were investigated for inhibitory activity toward the respective other enzyme. Additionally, novel derivatives were synthesized and biologically evaluated. By this means, the structural features needed for benzamidobenzoic acids to be potent and, most notably, selective PqsD inhibitors were identified. The most interesting compound of this study was the 3-Cl substituted compound 5 which strongly inhibits PqsD (IC 50 6.2 μM) while exhibiting no inhibition of RNAP.