158599-98-5Relevant academic research and scientific papers
3-Carboxy-20-keto steroids are dual uncompetitive inhibitors of human steroid 5α-reductase types 1 and 2
Yamashita, Dennis S.,Holt, Dennis A.,Oh, Hye-Ja,Shah, Dinu,Yen, Hwa-Kwo,Brandt, Martin,Levy, Mark A.
, p. 1481 - 1485 (1996)
Steroidal 3-carboxy-20-ketones have been prepared within two structural series, the androsta-3,5-dienes and the estra 1,3,5-trienes, as potential inhibitors of types 1 and 2 steroid 5α-reductase, the enzyme activity responsible for the final step in biosynthesis of dihydrotestosterone. These compounds are shown to be potent uncompetitive inhibitors of both human recombinant enzyme activities, defining a novel class of dual steroid 5α-reductase inhibitors.
