1586007-22-8Relevant academic research and scientific papers
Synthesis, characterization and antifungal evaluation of novel 2H-1,4-benzoxazin-3(4H)-one derivatives linked with a 1,2,3-triazole moiety
Jiang, Yuqin,Mao, Longfei,Zhu, Lin,Ren, Baoqi,Li, Wei,Xu, Guiqing
, p. 103 - 108 (2014)
In order to obtain novel bioactive compounds with significant antifungal activities, a series of 2H-1,4-benzoxazin-3(4H)-one analogs linked with a 1,2, 3-triazole moiety have been designed and synthesized via click reactions in a one-pot process at room temperature using CuCl as the catalyst. Their antifungal activities were tested against two plant-pathogenic fungi, Rhizoctonia cerealis (RC) and Colletotrichum capsici (CC). Statistical analysis showed that among the tested compounds in particular compound 3a exhibits a significant growth inhibitory activity against both RC and CC. All the synthesized compounds have been characterized by IR, HRMS and NMR experiments.
